Magnetization Transfer MRI in Pancreatic Cancer Xenograft Models

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2012 Jan 4

PMID 22213176

Citations 24

Authors

Weiguo Li

Zhuoli Zhang

Jodi Nicolai

Guang-Yu Yang

Reed A Omary

Andrew C Larson

Affiliations

Soon will be listed here.

Abstract

Magnetization transfer magnetic resonance imaging measurements were performed in three pancreatic ductal adenocarcinoma mouse xenograft models. For each of 28 pancreatic ductal adenocarcinoma xenografts, MT ratios (MTRs) were calculated and compared to histologic fibrosis levels from reference standard trichrome staining. MTR was found to be significantly higher in tumors grown using BxPC-3 cell line (39.4±5.1, mean±SD) compared to the MTR for the tumors grown from Panc-1 (32.4±2.8) and Capan-1 (27.3±2.9) cell lines (P<0.05 for each comparison). Histologic measurements showed a similar trend with BxPC-3 tumors demonstrating significantly higher fibrosis levels (percentage of fibrotic tissue area, 6.48±2.59) when compared to Panc-1 (3.54±2.18) and Capan-1 (2.07±1.60) tumors. MTR measurements were well correlated to quantitative fibrosis levels (r=0.69, P=0.01). Results indicated that MTR measurements offer the potential to serve as a valuable in vivo biomarker of desmoplasia in pancreatic ductal adenocarcinoma.

Citing Articles

Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography.

Reeves E, Li J, Zormpas-Petridis K, Boult J, Sullivan J, Cummings C Mol Oncol. 2023; 17(6):1076-1092.

PMID: 37081807 PMC: 10257424. DOI: 10.1002/1878-0261.13437.

Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy.

Deen S, McLean M, Gill A, Crawford R, Latimer J, Baldwin P BJR Open. 2022; 4(1):20210078.

PMID: 36105417 PMC: 9459873. DOI: 10.1259/bjro.20210078.

DWI Metrics Differentiating Benign Intraductal Papillary Mucinous Neoplasms from Invasive Pancreatic Cancer: A Study in GEM Models.

Joaquim M, Furth E, Fan Y, Song H, Pickup S, Cao J Cancers (Basel). 2022; 14(16).

PMID: 36011011 PMC: 9406679. DOI: 10.3390/cancers14164017.

Non-Invasive Monitoring of Increased Fibrotic Tissue and Hyaluronan Deposition in the Tumor Microenvironment in the Advanced Stages of Pancreatic Ductal Adenocarcinoma.

Vohra R, Wang Y, Son H, Totten S, Arora A, Maxwell A Cancers (Basel). 2022; 14(4).

PMID: 35205746 PMC: 8870395. DOI: 10.3390/cancers14040999.

Water and Collagen Content Are High in Pancreatic Cancer: Implications for Quantitative Metabolic Imaging.

Penet M, Kakkad S, Wildes F, Bhujwalla Z Front Oncol. 2021; 10:599204.

PMID: 33585215 PMC: 7873637. DOI: 10.3389/fonc.2020.599204.

References

Bonekamp S, Torbenson M, Kamel I . Diffusion-weighted magnetic resonance imaging for the staging of liver fibrosis. J Clin Gastroenterol. 2011; 45(10):885-92. PMC: 4337848. DOI: 10.1097/MCG.0b013e318223bd2c. View

Wang Y, Chen Z, Nikolaidis P, McCarthy R, Merrick L, Sternick L . Diffusion-weighted magnetic resonance imaging of pancreatic adenocarcinomas: association with histopathology and tumor grade. J Magn Reson Imaging. 2010; 33(1):136-42. DOI: 10.1002/jmri.22414. View

Fattahi R, Balci N, Perman W, Hsueh E, AlKaade S, Havlioglu N . Pancreatic diffusion-weighted imaging (DWI): comparison between mass-forming focal pancreatitis (FP), pancreatic cancer (PC), and normal pancreas. J Magn Reson Imaging. 2009; 29(2):350-6. DOI: 10.1002/jmri.21651. View

Strouch M, Cheon E, Salabat M, Krantz S, Gounaris E, Melstrom L . Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res. 2010; 16(8):2257-65. PMC: 3122919. DOI: 10.1158/1078-0432.CCR-09-1230. View

Gray M, Burstein D, Lesperance L, Gehrke L . Magnetization transfer in cartilage and its constituent macromolecules. Magn Reson Med. 1995; 34(3):319-25. DOI: 10.1002/mrm.1910340307. View

Char D, Barakos J, Cobbs C, Shiel M . Fibrous dysplasia. Orbit. 2010; 29(4):216-8. DOI: 10.3109/01676831003713991. View

Aisen A, Doi K, Swanson S . Detection of liver fibrosis with magnetic cross-relaxation. Magn Reson Med. 1994; 31(5):551-6. DOI: 10.1002/mrm.1910310513. View

Shami V, Mahajan A, Loch M, Stella A, Northup P, White G . Comparison between endoscopic ultrasound and magnetic resonance imaging for the staging of pancreatic cancer. Pancreas. 2011; 40(4):567-70. DOI: 10.1097/MPA.0b013e3182153b8c. View

Bali M, Metens T, Denolin V, Delhaye M, Demetter P, Closset J . Tumoral and nontumoral pancreas: correlation between quantitative dynamic contrast-enhanced MR imaging and histopathologic parameters. Radiology. 2011; 261(2):456-66. DOI: 10.1148/radiol.11103515. View

10.

Akoka S, Franconi F, Seguin F, Le Pape A . Radiofrequency map of an NMR coil by imaging. Magn Reson Imaging. 1993; 11(3):437-41. DOI: 10.1016/0730-725x(93)90078-r. View

11.

Imamura T, Iguchi H, Manabe T, Ohshio G, Yoshimura T, Wang Z . Quantitative analysis of collagen and collagen subtypes I, III, and V in human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis. Pancreas. 1995; 11(4):357-64. DOI: 10.1097/00006676-199511000-00007. View

12.

Neesse A, Michl P, Frese K, Feig C, Cook N, Jacobetz M . Stromal biology and therapy in pancreatic cancer. Gut. 2010; 60(6):861-8. DOI: 10.1136/gut.2010.226092. View

13.

Kuroki-Suzuki S, Kuroki Y, Nasu K, Nagashima C, Machida M, Muramatsu Y . Pancreatic cancer screening employing noncontrast magnetic resonance imaging combined with ultrasonography. Jpn J Radiol. 2011; 29(4):265-71. DOI: 10.1007/s11604-010-0554-6. View

14.

Kucharczyk W, Macdonald P, Stanisz G, Henkelman R . Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH. Radiology. 1994; 192(2):521-9. DOI: 10.1148/radiology.192.2.8029426. View

15.

Bailey J, Swanson B, Hamada T, Eggers J, Singh P, Caffery T . Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res. 2008; 14(19):5995-6004. PMC: 2782957. DOI: 10.1158/1078-0432.CCR-08-0291. View

16.

Seo G, Aoki J, Moriya H, Karakida O, Sone S, Hidaka H . Hyaline cartilage: in vivo and in vitro assessment with magnetization transfer imaging. Radiology. 1996; 201(2):525-30. DOI: 10.1148/radiology.201.2.8888253. View

17.

Luciani A, Vignaud A, Cavet M, Tran Van Nhieu J, Mallat A, Ruel L . Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study. Radiology. 2008; 249(3):891-9. DOI: 10.1148/radiol.2493080080. View

18.

Olive K, Jacobetz M, Davidson C, Gopinathan A, McIntyre D, Honess D . Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009; 324(5933):1457-61. PMC: 2998180. DOI: 10.1126/science.1171362. View

19.

Muraoka N, Uematsu H, Kimura H, Imamura Y, Fujiwara Y, Murakami M . Apparent diffusion coefficient in pancreatic cancer: characterization and histopathological correlations. J Magn Reson Imaging. 2008; 27(6):1302-8. DOI: 10.1002/jmri.21340. View

20.

Lequin R . Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin Chem. 2005; 51(12):2415-8. DOI: 10.1373/clinchem.2005.051532. View