The Melanoma 'epidemic': Lessons from Prostate Cancer
Overview
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The rise in malignant melanoma incidence has been termed "epidemic". Closer scrutiny of epidemiologic data suggests overdiagnosis as the true cause of the dramatic rise in melanoma incidence. In epidemiologic terms, "overdiagnosis" describes lesions that are histologically malignant but biologically benign. Overdiagnosis is not unique to melanoma screening but is prevalent in screening for cancers of other organs, including the thyroid and prostate glands.
Berlin A, Ramotar M, Santiago A, Liu Z, Li J, Wolinsky H J Natl Cancer Inst. 2023; 115(11):1364-1373.
PMID: 37285311 PMC: 10637044. DOI: 10.1093/jnci/djad108.
Barnhill R, Elder D, Piepkorn M, Knezevich S, Reisch L, Eguchi M JAMA Netw Open. 2023; 6(1):e2250613.
PMID: 36630138 PMC: 10375511. DOI: 10.1001/jamanetworkopen.2022.50613.
Cancer overdiagnosis: a challenge in the era of screening.
Dunn B, Woloshin S, Xie H, Kramer B J Natl Cancer Cent. 2022; 2(4):235-242.
PMID: 36568283 PMC: 9784987. DOI: 10.1016/j.jncc.2022.08.005.
Not Your Mother's Melanoma: Causes and Effects of Early Melanoma Diagnosis.
Sadrolashrafi K, Cotter D Dermatopathology (Basel). 2022; 9(4):368-378.
PMID: 36547217 PMC: 9777089. DOI: 10.3390/dermatopathology9040043.
Estimating Overdiagnosis of Melanoma Using Trends Among Black and White Patients in the US.
Adamson A, Suarez E, Welch H JAMA Dermatol. 2022; 158(4):426-431.
PMID: 35293957 PMC: 8928089. DOI: 10.1001/jamadermatol.2022.0139.