Neuritis of the Cauda Equina, a Chronic Idiopathic Polyradiculoneuritis in the Horse

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1979 Apr 12

PMID 222109

Citations 2

Authors

J F Cummings

A de Lahunta

J F Timoney

Affiliations

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Abstract

Four cases of neuritis of the cauda equina (NCE) were studied by light and electron microscopy. Examination of sacral intradural rootlets revealed inflammatory cell infiltrates and an array of myelinated fiber changes which included myelin stripping by invading mononuclear cells and macrophages, as well as splitting and vesiculation of myelin lamellae without obvious participation by leukocytes. More distally in the extradural roots, there was marked granulomatous inflammation, and demyelinative changes were overshadowed by widespread evidence of irreversible axon damage. In all cases, unusual crystalline inclusions appeared in the endoneurium and sheaths of the rootlets and fascicles. The changes in NCE were compared and contrasted with those observed in acute and chronic inflammatory demyelinative neuropathies.

Citing Articles

Cauda equina neuritis: a chronic idiopathic polyneuritis in two horses.

Rousseaux C, Futcher K, Clark E, Naylor J Can Vet J. 1984; 25(5):214-8.

PMID: 17422405 PMC: 1790566.

Coonhound paralysis. Further clinical studies and electron microscopic observations.

Cummings J, de Lahunta A, Holmes D, Schultz R Acta Neuropathol. 1982; 56(3):167-78.

PMID: 7072488 DOI: 10.1007/BF00690632.

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