Imaging Cardiac Extracellular Matrices: a Blueprint for Regeneration

Overview

Journal Trends Biotechnol

Specialty Biochemistry

Date 2012 Jan 3

PMID 22209562

Citations 12

Authors

Jangwook P Jung

Jayne M Squirrell

Gary E Lyons

Kevin W Eliceiri

Brenda M Ogle

Affiliations

Soon will be listed here.

Abstract

Once damaged, cardiac tissue does not readily repair and is therefore a primary target of regenerative therapies. One regenerative approach is the development of scaffolds that functionally mimic the cardiac extracellular matrix (ECM) to deliver stem cells or cardiac precursor populations to the heart. Technological advances in micro/nanotechnology, stem cell biology, biomaterials and tissue decellularization have propelled this promising approach forward. Surprisingly, technological advances in optical imaging methods have not been fully utilized in the field of cardiac regeneration. Here, we describe and provide examples to demonstrate how advanced imaging techniques could revolutionize how ECM-mimicking cardiac tissues are informed and evaluated.

Citing Articles

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