Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

Overview

Journal J Thyroid Res

Publisher Wiley

Specialty Endocrinology

Date 2011 Dec 29

PMID 22203918

Citations 5

Authors

P Torremante

F Flock

W Kirschner

Affiliations

Soon will be listed here.

Abstract

Preterm birth is the most common reason for perinatal morbidity and mortality in the western world. It has been shown that in euthyreotic pregnant women with thyroid autoimmune antibodies, L-Thyroxine replacement reduces preterm delivery rate in singleton pregnancies. We investigated in a nonrandomized retrospective observational study whether L-Thyroxine replacement, maintaining maternal free thyroxine serum level in the high normal reference range prescribed for nonpregnant women also influences the rate of preterm delivery in women without thyroid autoimmune antibodies. As control group for preterm delivery rate, data from perinatal statistics of the State of Baden-Württemberg from 2006 were used. The preterm delivery rate in the study group was significantly reduced. The subgroup analysis shows no difference in primiparous but a decline in multiparous by approximately 61% with L-Thyroxine replacement. Maintaining free thyroxine serum level in the high normal reference range prescribed for nonpregnant women may reduce the preterm delivery rate.

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The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: An updated systematic review and meta-analysis.

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Correspondence (reply): In reply.

Schleussner E Dtsch Arztebl Int. 2013; 110(33-34):560.

PMID: 24069086 PMC: 3782032. DOI: 10.3238/arztebl.2013.0560.

Correspondence (letter to the editor): thyroid function as a possible cause.

Torremante P Dtsch Arztebl Int. 2013; 110(33-34):558.

PMID: 24069082 PMC: 3782028. DOI: 10.3238/arztebl.2013.0558a.

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