The Effects of the Kampo Medicine (Japanese Herbal Medicine) "Daikenchuto" on the Surgical Inflammatory Response Following Laparoscopic Colorectal Resection

Overview

Journal Surg Today

Specialty General Surgery

Date 2011 Dec 29

PMID 22202972

Citations 22

Authors

Kozo Yoshikawa

Mitsuo Shimada

Masanori Nishioka

Nobuhiro Kurita

Takashi Iwata

Shinya Morimoto

Tomohiko Miyatani

Masato Komatsu

Hideya Kashihara

Chie Mikami

Affiliations

Soon will be listed here.

Abstract

Purposes: The inflammatory response after surgery is associated with various postoperative complications. The aim of the present prospective study was to evaluate the effects of Daikenchuto (DKT) (a Japanese herbal medicine) on the inflammatory response in patients following laparoscopic colorectal resection.

Methods: Thirty patients who underwent laparoscopic colectomy for colorectal carcinoma were divided into two groups: a DKT intake group (D group, n = 15) and a control group (C group, n = 15). The D group took 7.5 g/day of DKT from the day after surgery until the 7th postoperative day. The body temperature, heart rate, WBC count, lymphocyte count, C-reactive protein (CRP) level, β-D: -glucan level and Candida index were compared between the two groups.

Results: The patients' mean age in the D group was significantly younger than that in the C group. D3 lymph node dissection was performed more often in the D group. The time until first flatus was significantly shorter in the D group (1.8 ± 0.5 days) than in the C group (2.7 ± 0.5 days). The CRP level was significantly lower in the D group (4.6 ± 0.6 mg/dl) than in the C group (8.3 ± 1.1 mg/dl) on the 3rd postoperative day.

Conclusions: Postoperative DKT administration significantly suppressed the CRP level and shortened the time until first flatus. DKT administration also significantly suppressed postoperative inflammation following surgery for colorectal cancer.

Citing Articles

Efficacy of Daikenchuto in the prevention of bowel obstruction in patients with colorectal cancer undergoing laparoscopic surgery: An observational study using a Japanese administrative claims database.

Kunitomi Y, Nakashima M, Takeuchi M, Kawakami K Support Care Cancer. 2023; 31(2):133.

PMID: 36697914 DOI: 10.1007/s00520-023-07599-5.

Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound.

Suzuki K, Takehara Y, Sakata M, Kawate M, Ohishi N, Sugiyama K PLoS One. 2021; 16(1):e0245878.

PMID: 33503053 PMC: 7840032. DOI: 10.1371/journal.pone.0245878.

Kampo Medicine for Various Aging-Related Symptoms: A Review of Geriatric Syndrome.

Takayama S, Tomita N, Arita R, Ono R, Kikuchi A, Ishii T Front Nutr. 2020; 7:86.

PMID: 32766269 PMC: 7381143. DOI: 10.3389/fnut.2020.00086.

Daikenchuto improved perioperative nutritional status of the patients with colorectal cancer: A prospective open-labeled randomized exploratory study.

Fujita F, Torashima Y, Inoue Y, Ito S, Kobayashi K, Kanetaka K Interv Med Appl Sci. 2020; 11(2):84-88.

PMID: 32148910 PMC: 7044534. DOI: 10.1556/1646.11.2019.13.

Efficacy of daikenchuto, a traditional Japanese Kampo medicine, for postoperative intestinal dysfunction in patients with gastrointestinal cancers: meta-analysis.

Hosaka M, Arai I, Ishiura Y, Ito T, Seki Y, Naito T Int J Clin Oncol. 2019; 24(11):1385-1396.

PMID: 31297704 DOI: 10.1007/s10147-019-01502-1.

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