Maternal Protein Restriction Regulates IGF2 System in Placental Labyrinth

Overview

Journal Front Biosci (Elite Ed)

Specialty Biology

Date 2011 Dec 29

PMID 22201967

Citations 21

Authors

Haijun Gao

Kunju Reddiar Sathishkumar

Uma Yallampalli

Meena Balakrishnan

Xilong Li

Guoyao Wu

Chandra Yallampalli

Affiliations

Soon will be listed here.

Abstract

This study was to test the hypothesis that altered IGF2 system in the placental labyrinth zone (LZ) impairs feto-placental growth in response to maternal protein restriction. Rats were fed a 20% protein diet and an isocaloric 6 % protein diet (LP) from day 1 to days 14, 18, or 21 of pregnancy. The effects of diet, gender of placenta and fetus, and day of pregnancy on placental weight, fetal weight, and expression of the IGF2 axis in the placental LZ and amino acids in maternal plasma were analyzed. Growth restriction occurred in both female and male fetuses by LP, coincident with impaired LZ growth and efficiency. The expression of Igf2, Igf2P0, Igf1r, Igf2r, Insr, Igfbp1, and Igfbp2 in placental LZ were affected by diet, gender and/or day of pregnancy. Concentrations of total essential amino acids and total nonessential amino acids were reduced and increased, respectively, in maternal plasma of LP-fed rats. These results indicate that adaptation of the IGF2 system in rat LZ occurs in a sex- and time-dependent manner in response to maternal protein restriction; however, these adaptations cannot prevent the growth restriction of both male and female fetuses during late pregnancy.

Citing Articles

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Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction.

Eaton M, Davies A, Devine J, Zhao X, Simmons D, Mariusdottir E PLoS One. 2020; 15(1):e0226735.

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Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats.

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