Recent Advances on Tea Polyphenols

Overview

Journal Front Biosci (Elite Ed)

Specialty Biology

Date 2011 Dec 29

PMID 22201858

Citations 76

Authors

Jyoti Kanwar

Mujtaba Taskeen

Imthiyaz Mohammad

Congde Huo

Tak Hang Chan

Qing Ping Dou

Affiliations

Soon will be listed here.

Abstract

Over the past decade many scientific and medical studies have focused on green tea for its long-purported health benefits. There is convincing evidence that tea is a cup of life. It has multiple preventive and therapeutic effects. This review thus focuses on the recent advances of tea polyphenols and their applications in the prevention and treatment of human cancers. Of the various polyphenols in tea, (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant, and active compound studied in tea research. EGCG inhibits several molecular targets to inhibit cancer initiation and modulates several essential survival pathways to block cancer progression. Herein, we describe the various mechanisms of action of EGCG and also discuss previous and current ongoing clinical trials of EGCG and green tea polyphenols in different cancer types.

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