MicroRNAs and Their Roles in Osteoclast Differentiation

Overview

Journal Front Med

Specialty General Medicine

Date 2011 Dec 27

PMID 22198753

Citations 21

Authors

Zhuying Xia

Chao Chen

Peng Chen

Hui Xie

Xianghang Luo

Affiliations

Soon will be listed here.

Abstract

Osteoclasts, which are derived from monocyte-macrophage precursors, are exclusive bone resorption cells. Limited evidence indicates that a class of small non-coding single-stranded RNAs known as "microRNAs" (miRNAs) is also involved in bone resorption. Although various miRNAs regulate cell proliferation and differentiation, few miRNAs have been reported to play a key role in the regulation of osteoclast differentiation. In this short review, the biology and functional mechanisms of miRNAs in osteoclastogenesis are summarized. The profiling, function, and target prediction of miRNAs are discussed as well.

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