Should All Women with PCOS Be Treated for Insulin Resistance?

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2011 Dec 24

PMID 22192137

Citations 61

Authors

John C Marshall

Andrea Dunaif

Affiliations

Soon will be listed here.

Abstract

PRO--A large majority of women with PCOS have insulin resistance, compensatory hyperinsulinemia with consequent reproductive and metabolic abnormalities. Metformin has been shown to be effective therapy and could be used more widely in obese adolescents with hyperandrogenemia, a forerunner of PCOS. CON--The severity of insulin resistance is highly variable in women with PCOS and may not be clinically relevant in milder phenotypes. Treatment should be directed at specific metabolic or reproductive problems and insulin sensitizing drugs are not always the optimum therapy.

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