Variation in Age at Cancer Diagnosis in Familial Versus Nonfamilial Barrett's Esophagus

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2011 Dec 20

PMID 22178570

Citations 10

Authors

Amitabh Chak

Yanwen Chen

Jaime Vengoechea

Marcia I Canto

Robert Elston

Gary W Falk

William M Grady

Kishore Guda

Margaret Kinnard

Sanford Markowitz

Sumeet Mittal

Ganapathy Prasad

Nicholas Shaheen

Joseph E Willis

Jill S Barnholtz-Sloan

Affiliations

Soon will be listed here.

Abstract

Background: Genetic influences may be discerned in families that have multiple affected members and may manifest as an earlier age of cancer diagnosis. In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC).

Methods: Information on BE/EAC risk factors and family history was collected from probands at eight tertiary care academic hospitals. Age of cancer diagnosis and other risk factors were compared between nonfamilial (no affected relatives), duplex (two affected relatives), and multiplex (three or more affected relatives) FBE kindreds.

Results: The study included 830 nonfamilial, 274 duplex, and 41 multiplex FBE kindreds with 274, 133, and 43 EAC and 566, 288, and 103 BE cases, respectively. Multivariable mixed models adjusting for familial correlations showed that multiplex kindreds were associated with a younger age of cancer diagnosis (P = 0.0186). Median age of cancer diagnosis was significantly younger in multiplex compared with duplex and nonfamilial kindreds (57 vs. 62 vs. 63 years, respectively, P = 0.0448). Mean body mass index was significantly lower in multiplex kindreds (P = 0.0033), as was smoking (P < 0.0001), and reported regurgitation (P = 0.0014).

Conclusions: Members of multiplex FBE kindreds develop EAC at an earlier age compared with nonfamilial EAC cases. Multiplex kindreds do not have a higher proportion of common risk factors for EAC, suggesting that this aggregation might be related to a genetic factor.

Impact: These findings indicate that efforts to identify susceptibility genes for BE and EAC will need to focus on multiplex kindreds.

Citing Articles

Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.

Peters Y, van Grinsven E, Siersema P Aliment Pharmacol Ther. 2021; 54(7):868-879.

PMID: 34383966 PMC: 9292032. DOI: 10.1111/apt.16558.

Age of diagnosis in familial Barrett's associated neoplasia.

Glamour B, Alaber O, Cioffi G, Chandar A, Barnholtz-Sloan J, Brock W Fam Cancer. 2021; 21(1):115-120.

PMID: 33694069 PMC: 9469732. DOI: 10.1007/s10689-021-00239-z.

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.

Curtius K, Wong C, Hazelton W, Kaz A, Chak A, Willis J PLoS Comput Biol. 2016; 12(5):e1004919.

PMID: 27168458 PMC: 4864310. DOI: 10.1371/journal.pcbi.1004919.

The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

To H, Clemons N, Duong C, Trainer A, Phillips W Dig Dis Sci. 2016; 61(7):1826-34.

PMID: 26971090 DOI: 10.1007/s10620-016-4109-2.

Hereditary Factors in Esophageal Adenocarcinoma.

van Nistelrooij A, Dinjens W, Wagner A, Spaander M, van Lanschot J, Wijnhoven B Gastrointest Tumors. 2015; 1(2):93-8.

PMID: 26675496 PMC: 4645576. DOI: 10.1159/000362575.

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