Birth Defects in Singleton Versus Multiple ART Births in Japan (2004-2008)

Overview

Journal J Pregnancy

Publisher Wiley

Specialty Gynecology & Obstetrics

Date 2011 Dec 17

PMID 22175021

Citations 5

Authors

Syuichi Ooki

Affiliations

Soon will be listed here.

Abstract

The purpose of the present study was to evaluate the relative risk (RR) of multiple births for birth defects after assisted reproductive technology (ART) using Japanese nationwide data from 2004 to 2008 with singletons as the reference group. In multiples compared to singletons, the percentage of birth defects per pregnancy were significantly higher (RR = 1.88, 95% confidence interval (CI) 1.60-2.13), the percentage of birth defects per live birth was not significantly higher (RR = 0.90, 95% CI 0.78-1.05 or RR = 0.94, 95% CI 0.81-1.10), and the early neonatal mortality rate was significantly higher (RR = 2.68, 95% CI 1.52-4.70 or RR = 2.80, 95% CI 1.60-4.92). The early neonatal mortality per 10,000 live births was slightly higher in ART (5.09) than in the general population (3.86). We concluded that the impact of birth defects after ART would be larger in families with multiples compared to families with singletons, since the mean number of children would be larger in the former.

Citing Articles

Birth defects after assisted reproductive technology according to the method of treatment in Japan: nationwide data between 2004 and 2012.

Ooki S Environ Health Prev Med. 2015; 20(6):460-5.

PMID: 26296807 PMC: 4626456. DOI: 10.1007/s12199-015-0486-y.

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies.

Ricciarelli E, Bruna I, Verdu V, Torrello M, Herrer R, Gris J J Assist Reprod Genet. 2013; 30(7):897-905.

PMID: 23779097 PMC: 3725228. DOI: 10.1007/s10815-013-0023-0.

Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004-2010.

Ooki S Int J Womens Health. 2013; 5:65-77.

PMID: 23450007 PMC: 3581291. DOI: 10.2147/IJWH.S32296.

Congenital hypothyroidism after assisted reproductive technology in Japan: comparison between multiples and singletons, 2005-2009.

Ooki S Int J Pediatr Endocrinol. 2013; 2013(1):5.

PMID: 23402602 PMC: 3584851. DOI: 10.1186/1687-9856-2013-5.

Concordance rates of birth defects after assisted reproductive technology among 17 258 Japanese twin pregnancies: a nationwide survey, 2004-2009.

Ooki S J Epidemiol. 2012; 23(1):63-9.

PMID: 23132150 PMC: 3700233. DOI: 10.2188/jea.je20120103.

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