Immune Reconstitution Following Unmanipulated HLA-mismatched/haploidentical Transplantation Compared with HLA-identical Sibling Transplantation

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2011 Dec 17

PMID 22173879

Citations 36

Authors

Ying-Jun Chang

Xiang-Yu Zhao

Ming-Rui Huo

Lan-Ping Xu

Dai-Hong Liu

Kai-Yan Liu

Xiao-Jun Huang

Affiliations

Soon will be listed here.

Abstract

In this study, we prospectively investigated the immune reconstitution in patients with hematological malignancies after human leukocyte antigen (HLA)-mismatched/unmanipulated haploidentical transplantation (50 cases) and HLA-matched transplant (25 cases). Transplant-related mortality, relapse, leukemia-free survival, and overall survival were similar between the two transplant strategies, although the cumulative incidence of CMV antigenemia was significantly higher in haploidentical recipients than in HLA-matched recipients (49.9 ± 7.2% versus 13 ± 7%, P = 0.007). Compared with HLA-matched recipients, T-cell subset and dendritic cell subgroup cell counts in the first 90 days after grafting were lower in haploidentical recipients. The difference was most striking for CD4(+) and CD4(+) naïve T cells. Reconstitution of B cells and monocytes was comparable between groups. T cells appeared equally functional in both groups among patients without graft-versus-host disease. Our results suggest that the clinical outcomes were not compromised by the early delayed immune reconstitution following haploidentical transplantation.

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