Molecular Epidemiology of Rift Valley Fever Virus

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2011 Dec 17

PMID 22172568

Citations 92

Authors

Antoinette A Grobbelaar

Jacqueline Weyer

Patricia A Leman

Alan Kemp

Janusz T Paweska

Robert Swanepoel

Affiliations

Soon will be listed here.

Abstract

Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.

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