Ni-catalyzed Reductive Allylation of Unactivated Alkyl Halides with Allylic Carbonates

Overview

Journal Chemistry

Specialty Chemistry

Date 2011 Dec 16

PMID 22170740

Citations 15

Authors

Yijing Dai

Fan Wu

Zhenhua Zang

Hengzhi You

Hegui Gong

Affiliations

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Abstract

Game of two electrophiles: Two partially positively charged sp(3) carbon atoms can be connected by using a catalytic Ni species in the presence of an environmentally benign Zn reductant, delivering allylated alkanes. This unprecedented approach allowed a variety of unactivated alkyl halides and substituted allylic carbonates to regioselectively afford E-alkenes in good to excellent yields.

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