The Immunologic Revolution: Photoimmunology

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2011 Dec 16

PMID 22170491

Citations 42

Authors

Stephen E Ullrich

Scott N Byrne

Affiliations

Soon will be listed here.

Abstract

UV radiation targets the skin and is a primary cause of skin cancer (both melanoma and nonmelanoma skin cancer). Exposure to UV radiation also suppresses the immune response, and UV-induced immune suppression is a major risk factor for skin cancer induction. The efforts of dermatologists and cancer biologists to understand how UV radiation exposure suppresses the immune response and contributes to skin cancer induction led to the development of the subdiscipline we call photoimmunology. Advances in photoimmunology have generally paralleled advances in immunology. However, there are a number of examples in which investigations into the mechanisms underlying UV-induced immune suppression reshaped our understanding of basic immunological concepts. Unconventional immune regulatory roles for Langerhans cells, mast cells, and natural killer T (NKT) cells, as well as the immune-suppressive function of lipid mediators of inflammation and alarmins, are just some examples of how advances in immunodermatology have altered our understanding of basic immunology. In this anniversary issue celebrating 75 years of cutaneous science, we provide examples of how concepts that grew out of efforts by immunologists and dermatologists to understand immune regulation by UV radiation affected immunology in general.

Citing Articles

Curcumin-Loaded Liposomes in Gel Protect the Skin of Mice against Oxidative Stress from Photodamage Induced by UV Irradiation.

Zhang Y, Sun B, Wang L, Shen W, Shen S, Cheng X Gels. 2024; 10(9).

PMID: 39330198 PMC: 11431562. DOI: 10.3390/gels10090596.

Langerhans cells orchestrate apoptosis of DNA-damaged keratinocytes upon high-dose UVB skin exposure.

Ortner D, Strandt H, Tripp C, Spoeck S, Seretis A, Hornsteiner F Eur J Immunol. 2024; 54(12):e2451020.

PMID: 39288297 PMC: 11628926. DOI: 10.1002/eji.202451020.

Mast Cell: A Mysterious Character in Skin Cancer.

Alda S, Ceausu R, Gaje P, Raica M, Cosoroaba R In Vivo. 2023; 38(1):58-68.

PMID: 38148067 PMC: 10756458. DOI: 10.21873/invivo.13410.

Epstein-Barr virus infection, B-cell dysfunction and other risk factors converge in gut-associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesis.

Leffler J, Trend S, Hart P, French M Clin Transl Immunology. 2022; 11(11):e1418.

PMID: 36325491 PMC: 9621333. DOI: 10.1002/cti2.1418.

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.

Frommeyer T, Gilbert M, Brittain G, Wu T, Nguyen T, Rohan C Front Immunol. 2022; 13:880850.

PMID: 35603177 PMC: 9120817. DOI: 10.3389/fimmu.2022.880850.

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