Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

Overview

Journal Neural Plast

Specialty Neurology

Date 2011 Dec 14

PMID 22164341

Citations 18

Authors

Ignacio Gonzalez-Burgos

Martha C Rivera-Cervantes

Dulce A Velazquez-Zamora

Alfredo Feria-Velasco

Luis Miguel Garcia-Segura

Affiliations

Soon will be listed here.

Abstract

Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.

Citing Articles

Introduction: What Are Dendritic Spines?.

Rasia-Filho A, Calcagnotto M, von Bohlen Und Halbach O Adv Neurobiol. 2023; 34:1-68.

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Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43 Mouse Model of Amyotrophic Lateral Sclerosis.

Handley E, Reale L, Chuckowree J, Dyer M, Barnett G, Clark C Mol Neurobiol. 2022; 59(5):2962-2976.

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Selective estrogen receptor modulators in the prevention of breast cancer in premenopausal women: a review.

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Drug Repurposing for Alzheimer's Disease Based on Protein-Protein Interaction Network.

Soleimani Zakeri N, Pashazadeh S, MotieGhader H Biomed Res Int. 2021; 2021:1280237.

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The Subcortical-Allocortical- Neocortical for the Emergence and Morphological Heterogeneity of Pyramidal Neurons in the Human Brain.

Rasia-Filho A, Knak Guerra K, Vasquez C, DallOglio A, Reberger R, Jung C Front Synaptic Neurosci. 2021; 13:616607.

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