Serum Response Factor Mediated Gene Activity in Physiological and Pathological Processes of Neuronal Motility

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2011 Dec 14

PMID 22164132

Citations 8

Authors

Bernd Knoll

Affiliations

Soon will be listed here.

Abstract

In recent years, the transcription factor serum response factor (SRF) was shown to contribute to various physiological processes linked to neuronal motility. The latter include cell migration, axon guidance, and, e.g., synapse function relying on cytoskeletal dynamics, neurite outgrowth, axonal and dendritic differentiation, growth cone motility, and neurite branching. SRF teams up with myocardin related transcription factors (MRTFs) and ternary complex factors (TCFs) to mediate cellular actin cytoskeletal dynamics and the immediate-early gene (IEG) response, a bona fide indicator of neuronal activation. Herein, I will discuss how SRF and cofactors might modulate physiological processes of neuronal motility. Further, potential mechanisms engaged by neurite growth promoting molecules and axon guidance cues to target SRF's transcriptional machinery in physiological neuronal motility will be presented. Of note, altered cytoskeletal dynamics and rapid initiation of an IEG response are a hallmark of injured neurons in various neurological disorders. Thus, SRF and its MRTF and TCF cofactors might emerge as a novel trio modulating peripheral and central axon regeneration.

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References

Hertel M, Tretter Y, Alzheimer C, Werner S . Connective tissue growth factor: a novel player in tissue reorganization after brain injury?. Eur J Neurosci. 2000; 12(1):376-80. DOI: 10.1046/j.1460-9568.2000.00930.x. View

Paul A, Pohl-Guimaraes F, Krahe T, Filgueiras C, Lantz C, Colello R . Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. J Neurosci. 2010; 30(7):2513-20. PMC: 2830729. DOI: 10.1523/JNEUROSCI.5840-09.2010. View

Morgan J, Cohen D, Hempstead J, Curran T . Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 1987; 237(4811):192-7. DOI: 10.1126/science.3037702. View

Lykissas M, Batistatou A, Charalabopoulos K, Beris A . The role of neurotrophins in axonal growth, guidance, and regeneration. Curr Neurovasc Res. 2007; 4(2):143-51. DOI: 10.2174/156720207780637216. View

Demir O, Korulu S, Yildiz A, Karabay A, Kurnaz I . Elk-1 interacts with neuronal microtubules and relocalizes to the nucleus upon phosphorylation. Mol Cell Neurosci. 2008; 40(1):111-9. DOI: 10.1016/j.mcn.2008.10.004. View

Herdegen T, Waetzig V . AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene. 2001; 20(19):2424-37. DOI: 10.1038/sj.onc.1204387. View

Morris T, Jafari N, Rice A, Vasconcelos O, DeLorenzo R . Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes. J Neurosci. 1999; 19(19):8234-43. PMC: 6783053. View

Tetzlaff W, Bisby M, Kreutzberg G . Changes in cytoskeletal proteins in the rat facial nucleus following axotomy. J Neurosci. 1988; 8(9):3181-9. PMC: 6569438. View

Sun K, Battle M, Misra R, Duncan S . Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. Hepatology. 2009; 49(5):1645-54. PMC: 2810404. DOI: 10.1002/hep.22834. View

10.

Stern S, Debre E, Stritt C, Berger J, Posern G, Knoll B . A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription. J Neurosci. 2009; 29(14):4512-8. PMC: 6665722. DOI: 10.1523/JNEUROSCI.0333-09.2009. View

11.

Charvet C, Houbron C, Parlakian A, Giordani J, Lahoute C, Bertrand A . New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways. Mol Cell Biol. 2006; 26(17):6664-74. PMC: 1592825. DOI: 10.1128/MCB.00138-06. View

12.

Mokalled M, Johnson A, Kim Y, Oh J, Olson E . Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010; 137(14):2365-74. PMC: 2889604. DOI: 10.1242/dev.047605. View

13.

Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M . Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A. 2009; 106(1):316-21. PMC: 2629236. DOI: 10.1073/pnas.0806518106. View

14.

Chang S, Poser S, Xia Z . A novel role for serum response factor in neuronal survival. J Neurosci. 2004; 24(9):2277-85. PMC: 6730428. DOI: 10.1523/JNEUROSCI.4868-03.2004. View

15.

Bernstein B, Bamburg J . ADF/cofilin: a functional node in cell biology. Trends Cell Biol. 2010; 20(4):187-95. PMC: 2849908. DOI: 10.1016/j.tcb.2010.01.001. View

16.

Herdegen T, Skene P, Bahr M . The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 1997; 20(5):227-31. DOI: 10.1016/s0166-2236(96)01000-4. View

17.

Herdegen T, Zimmermann M . Immediate early genes (IEGs) encoding for inducible transcription factors (ITFs) and neuropeptides in the nervous system: functional network for long-term plasticity and pain. Prog Brain Res. 1995; 104:299-321. DOI: 10.1016/s0079-6123(08)61797-5. View

18.

Teg Pipes G, Creemers E, Olson E . The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 2006; 20(12):1545-56. DOI: 10.1101/gad.1428006. View

19.

Tetzlaff W, Alexander S, Miller F, Bisby M . Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J Neurosci. 1991; 11(8):2528-44. PMC: 6575511. View

20.

Barrett L, Van Bockstaele E, Sul J, Takano H, Haydon P, Eberwine J . Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Proc Natl Acad Sci U S A. 2006; 103(13):5155-60. PMC: 1458810. DOI: 10.1073/pnas.0510477103. View