L-carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma

Overview

Journal J Allergy (Cairo)

Specialty Allergy & Immunology

Date 2011 Dec 14

PMID 22162707

Citations 12

Authors

Mohammed Al-Biltagi

Mona Isa

Adel Salah Bediwy

Nevien Helaly

Dalia D El Lebedy

Affiliations

Soon will be listed here.

Abstract

The objective. was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods. Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group was randomly divided into two subgroups. Subgroup A was supplemented with L-carnitine for 6 months while subgroup B was used as a placebo controls. Both subgroups were assessed by pulmonary function tests (PFT) and childhood-asthma control test (C-ACT) before and 6 months after carnitine supplementation. Results. Total and free carnitine levels were significantly lower in patient group than in control group. PFT and C-ACT showed significant improvements in asthmatic children supplemented with L-carnitine than in those who were not supplemented. Conclusion. L-carnitine levels were initially lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation showed statistically significant improvement of C-ACT and PFT.

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