Role of NYGGF4 in Insulin Resistance

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2011 Dec 14

PMID 22160469

Citations 2

Authors

Xiaoling Chen

Zhiqing Huang

Daiwen Chen

Gang Jia

Xiangbing Mao

Xiuqun Wu

Affiliations

Soon will be listed here.

Abstract

Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin. A major factor in the development of insulin resistance syndrome is obesity. NYGGF4 is a novel gene that is abundantly expressed in the adipose tissue of obese subjects. NYGGF4 induced the secretion of FFAs and TNF-α and caused mitochondrial dysfunction, which may cause insulin resistance. This review will summarize the effect of NYGGF4 on the adipogenesis, glucose uptake and mitochondrial dysfunction in vitro, and the possible mechanism and signal pathway of NYGGF4 for insulin resistance.

Citing Articles

PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation.

Yin C, Liu W, Liu Y, Wang L, Xiao Y PLoS One. 2019; 14(4):e0214606.

PMID: 30990811 PMC: 6467375. DOI: 10.1371/journal.pone.0214606.

PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB.

Xu J, Ren X, Pathania A, Fernandez G, Tran A, Zhang Y Sci Rep. 2017; 7(1):835.

PMID: 28400607 PMC: 5429784. DOI: 10.1038/s41598-017-00947-6.

References

Zhang C, Zeng X, Zhang R, Ji C, Tong M, Chi X . Effects of NYGGF4 knockdown on insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes. J Bioenerg Biomembr. 2010; 42(5):433-9. DOI: 10.1007/s10863-010-9313-8. View

Schrauwen P, Hesselink M . Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes. 2004; 53(6):1412-7. DOI: 10.2337/diabetes.53.6.1412. View

Spiegelman B . Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found Symp. 2007; 287:60-3. View

Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M . Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol. 2003; 17(3):487-97. DOI: 10.1210/me.2002-0131. View

Walley A, Asher J, Froguel P . The genetic contribution to non-syndromic human obesity. Nat Rev Genet. 2009; 10(7):431-42. DOI: 10.1038/nrg2594. View

Finck B, Kelly D . PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest. 2006; 116(3):615-22. PMC: 1386111. DOI: 10.1172/JCI27794. View

Selman C, McLaren J, Himanka M, Speakman J . Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal. Free Radic Biol Med. 2000; 28(8):1279-85. DOI: 10.1016/s0891-5849(00)00263-x. View

Boveris A, Oshino N, Chance B . The cellular production of hydrogen peroxide. Biochem J. 1972; 128(3):617-30. PMC: 1173814. DOI: 10.1042/bj1280617. View

Yu B, Poirier L, Nagy L . Mobilization of GLUT-4 from intracellular vesicles by insulin and K(+) depolarization in cultured H9c2 myotubes. Am J Physiol. 1999; 277(2):E259-67. DOI: 10.1152/ajpendo.1999.277.2.E259. View

10.

Kim J, Wei Y, Sowers J . Role of mitochondrial dysfunction in insulin resistance. Circ Res. 2008; 102(4):401-14. PMC: 2963150. DOI: 10.1161/CIRCRESAHA.107.165472. View

11.

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F . Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?. Diabetes. 2001; 50(4):803-9. DOI: 10.2337/diabetes.50.4.803. View

12.

Inoguchi T, Sonta T, Tsubouchi H, Etoh T, Kakimoto M, Sonoda N . Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase. J Am Soc Nephrol. 2003; 14(8 Suppl 3):S227-32. DOI: 10.1097/01.asn.0000077407.90309.65. View

13.

Chiu P, Chaudhuri S, Harding P, Kopchick J, Donkin S, Etherton T . Cloning of a pig glucose transporter 4 cDNA fragment: use in developing a sensitive ribonuclease protection assay for quantifying low-abundance glucose transporter 4 mRNA in porcine adipose tissue. J Anim Sci. 1994; 72(5):1196-203. DOI: 10.2527/1994.7251196x. View

14.

LEHMAN J, Barger P, Kovacs A, Saffitz J, Medeiros D, Kelly D . Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000; 106(7):847-56. PMC: 517815. DOI: 10.1172/JCI10268. View

15.

Zhao Y, Zhang C, Chen X, Gao C, Ji C, Chen F . Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes. Mol Cell Biochem. 2010; 340(1-2):41-8. DOI: 10.1007/s11010-010-0398-5. View

16.

Zablocka A, Janusz M . [The two faces of reactive oxygen species]. Postepy Hig Med Dosw (Online). 2008; 62:118-24. View

17.

Nishikawa T, Edelstein D, Du X, Yamagishi S, Matsumura T, Kaneda Y . Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000; 404(6779):787-90. DOI: 10.1038/35008121. View

18.

Kahn B, Flier J . Obesity and insulin resistance. J Clin Invest. 2000; 106(4):473-81. PMC: 380258. DOI: 10.1172/JCI10842. View

19.

Vankoningsloo S, Piens M, Lecocq C, Gilson A, De Pauw A, Renard P . Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose. J Lipid Res. 2005; 46(6):1133-49. DOI: 10.1194/jlr.M400464-JLR200. View

20.

Mueckler M . Facilitative glucose transporters. Eur J Biochem. 1994; 219(3):713-25. DOI: 10.1111/j.1432-1033.1994.tb18550.x. View