Serum Vitamin D Concentration Status and Its Correlation with Early Biomarkers of Remodeling Following Acute Myocardial Infarction

Overview

Journal Clin Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 2011 Dec 14

PMID 22159952

Citations 24

Authors

Hossein Khalili

Azita Hajhossein Talasaz

Mojtaba Salarifar

Affiliations

Soon will be listed here.

Abstract

Background: Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients' outcomes, particularly on the early biomarkers of myocardial remodeling.

Methods: In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients' 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated.

Results: From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34-6.37, P < 0.05) and (OR = 2.36; CI = 1.05-5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients' survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011).

Conclusion: The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients' mortality in this study.

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References

Scragg R, Holdaway I, Jackson R, Lim T . Plasma 25-hydroxyvitamin D3 and its relation to physical activity and other heart disease risk factors in the general population. Ann Epidemiol. 1992; 2(5):697-703. DOI: 10.1016/1047-2797(92)90014-h. View

Zittermann A, Jungvogel A, Prokop S, Kuhn J, Dreier J, Fuchs U . Vitamin D deficiency is an independent predictor of anemia in end-stage heart failure. Clin Res Cardiol. 2011; 100(9):781-8. DOI: 10.1007/s00392-011-0312-5. View

Muray S, Parisi E, Cardus A, Craver L, Fernandez E . Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens. 2003; 21(11):2069-75. DOI: 10.1097/01.hjh.0000098139.70956.21. View

Scragg R, Sowers M, Bell C . Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens. 2007; 20(7):713-9. DOI: 10.1016/j.amjhyper.2007.01.017. View

Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B . Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008; 168(12):1340-9. DOI: 10.1001/archinte.168.12.1340. View

Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen O, Ljunghall S . Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens. 1995; 8(9):894-901. DOI: 10.1016/0895-7061(95)00154-H. View

Snijder M, Lips P, Seidell J, Visser M, Deeg D, Dekker J . Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women. J Intern Med. 2007; 261(6):558-65. DOI: 10.1111/j.1365-2796.2007.01778.x. View

Hintzpeter B, Mensink G, Thierfelder W, Muller M, Scheidt-Nave C . Vitamin D status and health correlates among German adults. Eur J Clin Nutr. 2007; 62(9):1079-89. DOI: 10.1038/sj.ejcn.1602825. View

Hypponen E, Boucher B, Berry D, Power C . 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes. 2007; 57(2):298-305. DOI: 10.2337/db07-1122. View

10.

Kendrick J, Targher G, Smits G, Chonchol M . 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis. 2008; 205(1):255-60. DOI: 10.1016/j.atherosclerosis.2008.10.033. View

11.

Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M . Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health. 2004; 4:38. PMC: 517720. DOI: 10.1186/1471-2458-4-38. View

12.

Grandi N, Breitling L, Vossen C, Hahmann H, Wusten B, Marz W . Serum vitamin D and risk of secondary cardiovascular disease events in patients with stable coronary heart disease. Am Heart J. 2010; 159(6):1044-51. DOI: 10.1016/j.ahj.2010.03.031. View

13.

Giovannucci E, Liu Y, Hollis B, Rimm E . 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008; 168(11):1174-80. PMC: 3719391. DOI: 10.1001/archinte.168.11.1174. View

14.

Li Y, Kong J, Wei M, Chen Z, Liu S, Cao L . 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002; 110(2):229-38. PMC: 151055. DOI: 10.1172/JCI15219. View

15.

Scragg R, Jackson R, Holdaway I, Lim T, Beaglehole R . Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol. 1990; 19(3):559-63. DOI: 10.1093/ije/19.3.559. View

16.

Sutton M, Sharpe N . Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation. 2000; 101(25):2981-8. DOI: 10.1161/01.cir.101.25.2981. View

17.

Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D . Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 2008; 74(2):170-9. DOI: 10.1038/ki.2008.101. View

18.

Pilz S, Tomaschitz A, Ritz E, Pieber T . Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol. 2009; 6(10):621-30. DOI: 10.1038/nrcardio.2009.135. View

19.

Resnick L, Muller F, LARAGH J . Calcium-regulating hormones in essential hypertension. Relation to plasma renin activity and sodium metabolism. Ann Intern Med. 1986; 105(5):649-54. DOI: 10.7326/0003-4819-105-5-649. View

20.

Reis J, von Muhlen D, Kritz-Silverstein D, Wingard D, Barrett-Connor E . Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 2007; 30(6):1549-55. DOI: 10.2337/dc06-2438. View