Regional Excitatory and Inhibitory Amino Acid Levels in Epileptic El Mouse Brain

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1990 Aug 1

PMID 2215861

Citations 8

Authors

M Hiramatsu

R Edamatsu

S Suzuki

M Shimada

A Mori

Affiliations

Soon will be listed here.

Abstract

Inbred mutant El mice are highly susceptible to convulsive seizures upon "tossing" stimulation. The levels of excitatory (e.g. glutamate and aspartate) and inhibitory amino acids [e.g. gamma-amino-butyrate (GABA)] were examined in discrete regions of stimulated El mice [El(+)], non-stimulated El mice [El(-)] and ddY mice, which do not have convulsive disposition. In comparison with ddY, a general increased levels of aspartate, glutamate, glutamine, and taurine were detected in brain regions of El(-). The levels of GABA and glycine were almost the same in ddY and El(-). Compared to El(+), the levels of aspartate, glutamate, glutamine, and GABA in El(-) were either the same or higher. In the case of taurine and glycine, the levels in El(-) were either the same or lower than El(+). Alanine is special in that El(-) have a higher level than El(+) in hippocampus but lower in cerebellum. Furthermore, while marked changes were registered in several brain regions, none of the amino acids investigated showed any significant differences in the hypothalamus of three different groups of mice.

Citing Articles

Neuronal mechanism of epileptogenesis in EL mouse.

Suzuki J Proc Jpn Acad Ser B Phys Biol Sci. 2013; 89(6):270-80.

PMID: 23759944 PMC: 3749469. DOI: 10.2183/pjab.89.270.

Akitane Mori, the artistic neurochemist.

Liu J, Hiramatsu M Neurochem Res. 2008; 34(4):593-600.

PMID: 18937068 DOI: 10.1007/s11064-008-9862-y.

Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.

Yamashita H, Ohno K, Amada Y, Inami H, Shishikura J, Sakamoto S Naunyn Schmiedebergs Arch Pharmacol. 2004; 370(2):99-105.

PMID: 15322731 DOI: 10.1007/s00210-004-0953-2.

Disturbances of amino acids from temporal lobe synaptosomes in human complex partial epilepsy.

Labiner D, Yan C, Weinand M, Huxtable R Neurochem Res. 1999; 24(11):1379-83.

PMID: 10555778 DOI: 10.1023/a:1022528522373.

Shifted cytosolic NADP+-dependent isocitrate dehydrogenase on 2-D gel in the brain of genetically epileptic E1 mice.

Ohmori O, Hirano H, Mita T Neurochem Res. 1999; 24(3):365-9.

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References

Bonhaus D, Laird H, Huxtable R . Decreased taurine transport in epileptic rats. Proc West Pharmacol Soc. 1982; 25:25-8. View

Fukahori M, Itoh M, Oomagari K, Kawasaki H . Zinc content in discrete hippocampal and amygdaloid areas of the epilepsy (El) mouse and normal mice. Brain Res. 1988; 455(2):381-4. DOI: 10.1016/0006-8993(88)90099-6. View

BERGAMINI L, Mutani R, Delsedime M, Durelli L . First clinical experience on the antiepileptic action of taurine. Eur Neurol. 1974; 11(5):261-9. DOI: 10.1159/000114324. View

BERL S, Purpura D, GIRADO M, WAELSCH H . Amino acid metabolism in epileptogenic and non-epileptogenic lesions of the neocortex (cat). J Neurochem. 1959; 4:311-7. DOI: 10.1111/j.1471-4159.1959.tb13210.x. View

van Gelder N . Antagonism by taurine of cobalt induced epilepsy in cat and mouse. Brain Res. 1972; 47(1):157-65. DOI: 10.1016/0006-8993(72)90259-4. View

Shimada M, Kabuto H, Yokoi I . The effect of omega-phosphono-alpha-aminocarboxylic acids on seizures and brain amino acid levels in E1 mice. Res Commun Chem Pathol Pharmacol. 1987; 57(3):359-73. View

van Gelder N, SHERWIN A, Rasmussen T . Amino acid content of epileptogenic human brain: focal versus surrounding regions. Brain Res. 1972; 40(2):385-93. DOI: 10.1016/0006-8993(72)90141-2. View

Balcar V, Pumain R, Mark J, Borg J, Mandel P . GABA-mediated inhibition in the epileptogenic focus, a process which may be involved in the mechanism of the cobalt-induced epilepsy. Brain Res. 1978; 154(1):182-5. DOI: 10.1016/0006-8993(78)91069-7. View

Yamagami S, Ohno K, Tsuji M, Mori K, Kawakita Y . Developmental alteration in RNA metabolism of E1 mouse brain. Folia Psychiatr Neurol Jpn. 1981; 35(3):253-60. DOI: 10.1111/j.1440-1819.1981.tb00223.x. View

10.

Suzuki J, Nakamoto Y, Shinkawa Y . Local cerebral glucose utilization in epileptic seizures of the mutant El mouse. Brain Res. 1983; 266(2):359-63. DOI: 10.1016/0006-8993(83)90670-4. View

11.

Emson P, Joseph M . Neurochemical and morphological changes during the development of cobalt-induced epilepsy in the rat. Brain Res. 1975; 93(1):91-110. DOI: 10.1016/0006-8993(75)90288-7. View

12.

Kurokawa M, Naruse H, Kato M . Metabolic studies on ep mouse, a special strain with convulsive predisposition. Prog Brain Res. 1966; 21:112-29. DOI: 10.1016/s0079-6123(08)62974-x. View

13.

Izumi K, Igisu H, Fukuda T . Effects of edetate on seizure suppressing actions of taurine and GABA. Brain Res. 1975; 88(3):576-9. DOI: 10.1016/0006-8993(75)90675-7. View

14.

Hiramatsu M, Ogawa K, Kabuto H, Mori A . Reduced uptake and release of 5-hydroxytryptamine and taurine in the cerebral cortex of epileptic El mice. Epilepsy Res. 1987; 1(1):40-5. DOI: 10.1016/0920-1211(87)90049-0. View

15.

Koyama I . Amino acids in the cobalt-induced epileptogenic and nonepileptogenic cat's cortex. Can J Physiol Pharmacol. 1972; 50(8):740-52. DOI: 10.1139/y72-109. View

16.

Hiramatsu M, Mori A . Reduced and oxidized glutathione in brain and convulsions. Neurochem Res. 1981; 6(3):301-6. DOI: 10.1007/BF00964045. View

17.

Suzuki J . Paroxysmal discharges in the electroencephalogram of the E1 mouse. Experientia. 1976; 32(3):336-8. DOI: 10.1007/BF01940824. View

18.

Suzuki J, Nakamoto Y . Seizure patterns and electroencephalograms of E1 mouse. Electroencephalogr Clin Neurophysiol. 1977; 43(3):299-311. DOI: 10.1016/0013-4694(77)90253-x. View

19.

Hiramatsu M, Kabuto H, Kwon M, Ishii A, Mori A . Depressed convulsions by diazepam and its effects on brain monoamines and amino acids in E1 mice. Epilepsy Res. 1988; 2(3):182-6. DOI: 10.1016/0920-1211(88)90055-1. View

20.

Mody I, Baimbridge K, Miller J . Distribution of Calbindin-D28K 1 (CaBP) in the cerebral cortex and hippocampus of the epileptic (El) mouse. Epilepsy Res. 1987; 1(1):46-52. DOI: 10.1016/0920-1211(87)90050-7. View