Safer Conception Interventions for HIV-affected Couples: Implications for Resource-constrained Settings

Overview

Journal Top Antivir Med

Specialties Infectious Diseases
Microbiology

Date 2011 Dec 14

PMID 22156217

Citations 26

Authors

Rachelle J Chadwick

Joanne E Mantell

Jennifer Moodley

Jane Harries

Virginia Zweigenthal

Diane Cooper

Affiliations

Soon will be listed here.

Abstract

Developing and testing safer conception methods that reduce HIV transmission to HIV-seronegative partners in serodiscordant couples and reduce superinfection in HIV-seroconcordant couples is a crucial but often unaddressed component of HIV prevention programs. Most research has focused on developed-world settings, where "high-technology" assisted reproduction techniques are used for HIV-serodiscordant couples in which the male is HIV-infected. There is a dearth of research on safer conception methods for HIV-seropositive women and "low-technology" harm-reduction strategies for HIV-affected couples, including vaginal insemination for HIV-seropositive women and natural conception methods for HIV-seroconcordant and -serodiscordant couples. This review summarizes international studies of safer conception interventions for HIV-affected couples, with a focus on feasibility in public-sector health settings where assisted reproductive technology is not readily available. Given that such low-technology options are feasible in most settings, well-designed, prospective interventions offering low-technology safer conception methods need to be developed and tested.

Citing Articles

Safer conception for female sex workers living with HIV in Dar es Salaam, Tanzania: Cross-sectional analysis of needs and opportunities in integrated family planning/HIV services.

Yam E, Kahabuka C, Mbita G, Winani K, Apicella L, Casalini C PLoS One. 2020; 15(7):e0235739.

PMID: 32692777 PMC: 7373272. DOI: 10.1371/journal.pone.0235739.

Predictors of Safer Conception Practices Among HIV-Infected Women in Northern Nigeria.

Iliyasu Z, Galadanci H, Oladimeji A, Babashani M, Gajida A, Aliyu M Int J Health Policy Manag. 2019; 8(8):480-487.

PMID: 31441288 PMC: 6706964. DOI: 10.15171/ijhpm.2019.27.

Sexual Relationship Power and Periconception HIV-Risk Behavior Among HIV-Infected Men in Serodifferent Relationships.

Khidir H, Mosery N, Greener R, Milford C, Bennett K, Kaida A AIDS Behav. 2019; 24(3):881-890.

PMID: 31165395 PMC: 6891132. DOI: 10.1007/s10461-019-02536-2.

Clients' experiences utilizing a safer conception service for HIV affected individuals: implications for differentiated care service delivery models.

Schwartz S, Davies N, Naidoo N, Pillay D, Makhoba N, Mullick S Reprod Health. 2019; 16(Suppl 1):65.

PMID: 31138252 PMC: 6538560. DOI: 10.1186/s12978-019-0718-5.

Human Immunodeficiency Virus Serodiscordance and Dual Contraceptive Method Use Among Human Immunodeficiency Virus-infected Men and Women in Lilongwe, Malawi.

Gausi B, Chagomerana M, Tang J, Hosseinipour M, Haddad L, Hannock T Sex Transm Dis. 2018; 45(11):747-753.

PMID: 30303948 PMC: 6200388. DOI: 10.1097/OLQ.0000000000000868.

References

Grant R, Lama J, Anderson P, McMahan V, Liu A, Vargas L . Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010; 363(27):2587-99. PMC: 3079639. DOI: 10.1056/NEJMoa1011205. View

Pena J, Thornton M, Sauer M . Assessing the clinical utility of in vitro fertilization with intracytoplasmic sperm injection in human immunodeficiency virus type 1 serodiscordant couples: report of 113 consecutive cycles. Fertil Steril. 2003; 80(2):356-62. DOI: 10.1016/s0015-0282(03)00662-9. View

Coll O, Lopez M, Hernandez S . Fertility choices and management for HIV-positive women. Curr Opin HIV AIDS. 2009; 3(2):186-92. DOI: 10.1097/COH.0b013e3282f51219. View

. Revised guidelines for HIV counseling, testing, and referral. MMWR Recomm Rep. 2001; 50(RR-19):1-57; quiz CE1-19a1-CE6-19a1. View

Garrido N, Meseguer M, Bellver J, Remohi J, Simon C, Pellicer A . Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples. Hum Reprod. 2004; 19(11):2581-6. DOI: 10.1093/humrep/deh460. View

Thornton A, Romanelli F, Collins J . Reproduction decision making for couples affected by HIV: a review of the literature. Top HIV Med. 2004; 12(2):61-7. View

van der Straten A, Gomez C, Saul J, Quan J, Padian N . Sexual risk behaviors among heterosexual HIV serodiscordant couples in the era of post-exposure prevention and viral suppressive therapy. AIDS. 2000; 14(4):F47-54. DOI: 10.1097/00002030-200003100-00003. View

van Leeuwen E, Repping S, Prins J, Reiss P, van der Veen F . Assisted reproductive technologies to establish pregnancies in couples with an HIV-1-infected man. Neth J Med. 2009; 67(8):322-7. View

Warszawski J, Tubiana R, Chenadec J, Blanche S, Teglas J, Dollfus C . Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS. 2007; 22(2):289-99. DOI: 10.1097/QAD.0b013e3282f3d63c. View

10.

Attia S, Egger M, Muller M, Zwahlen M, Low N . Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009; 23(11):1397-404. DOI: 10.1097/QAD.0b013e32832b7dca. View

11.

Nicopoullos J, Almeida P, Vourliotis M, Goulding R, Gilling-Smith C . A decade of sperm washing: clinical correlates of successful insemination outcome. Hum Reprod. 2010; 25(8):1869-76. DOI: 10.1093/humrep/deq134. View

12.

Geddes R, Knight S, Reid S, Giddy J, Esterhuizen T, Roberts C . Prevention of mother-to-child transmission of HIV programme: low vertical transmission in KwaZulu-Natal, South Africa. S Afr Med J. 2008; 98(6):458-62. View

13.

Nicopoullos J, Almeida P, Ramsay J, Gilling-Smith C . The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing. Hum Reprod. 2004; 19(10):2289-97. DOI: 10.1093/humrep/deh426. View

14.

Ezeanochie M, Olagbuji B, Ande A, Oboro V . Fertility preferences, condom use, and concerns among HIV-positive women in serodiscordant relationships in the era of antiretroviral therapy. Int J Gynaecol Obstet. 2009; 107(2):97-8. DOI: 10.1016/j.ijgo.2009.06.013. View

15.

Bujan L, Pasquier C, Labeyrie E, Lanusse-Crousse P, Morucci M, Daudin M . Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child. Fertil Steril. 2004; 82(4):857-62. DOI: 10.1016/j.fertnstert.2004.02.128. View

16.

Barreiro P, Del Romero J, Leal M, Hernando V, Asencio R, de Mendoza C . Natural pregnancies in HIV-serodiscordant couples receiving successful antiretroviral therapy. J Acquir Immune Defic Syndr. 2006; 43(3):324-6. DOI: 10.1097/01.qai.0000243091.40490.fd. View

17.

Myer L, Carter R, Katyal M, Toro P, El-Sadr W, Abrams E . Impact of antiretroviral therapy on incidence of pregnancy among HIV-infected women in Sub-Saharan Africa: a cohort study. PLoS Med. 2010; 7(2):e1000229. PMC: 2817715. DOI: 10.1371/journal.pmed.1000229. View

18.

Mandelbrot L, Heard I, Henrion R . Natural conception in HIV-negative women with HIV-infected partners. Lancet. 1997; 349(9055):850-1. DOI: 10.1016/S0140-6736(05)61754-0. View

19.

Rhodes R . Moral deliberation about fertility treatment for HIV-1 serodiscordant couples. Am J Bioeth. 2003; 3(1):50-3. DOI: 10.1162/152651603321612006. View

20.

Tonwe-Gold B, Ekouevi D, Viho I, Amani-Bosse C, Toure S, Coffie P . Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach. PLoS Med. 2007; 4(8):e257. PMC: 1949842. DOI: 10.1371/journal.pmed.0040257. View