Blood Serum MiRNA: Non-invasive Biomarkers for Alzheimer's Disease

Overview

Journal Exp Neurol

Specialty Neurology

Date 2011 Dec 14

PMID 22155483

Citations 151

Authors

Hirosha Geekiyanage

Gregory A Jicha

Peter T Nelson

Christina Chan

Affiliations

Soon will be listed here.

Abstract

There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.

Citing Articles

The Role of miR-137 in Neurodegenerative Disorders.

Bodai L, Borosta R, Ferencz A, Kovacs M, Zsindely N Int J Mol Sci. 2024; 25(13).

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