The Impact of Metal Sequestration on Staphylococcus Aureus Metabolism

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 2011 Dec 14

PMID 22153710

Citations 20

Authors

Neal D Hammer

Eric P Skaar

Affiliations

Soon will be listed here.

Abstract

The Gram-positive pathogen Staphylococcus aureus poses a serious risk to public health due to its prevalence as a commensal organism, its ability to cause a multitude of diseases, and the increasing incidence of antibiotic resistant strains. S. aureus infects diverse niches within vertebrates despite being challenged by a robust immune response. The host-pathogen confrontation occurs in an environment nearly devoid of metals that are essential for bacterial proliferation. S. aureus is able to flourish in these conditions and often causes significant morbidity and mortality. This review highlights current themes pertaining to the process of host-mediated metal sequestration known as 'nutritional immunity', S. aureus metal acquisition strategies, and how proliferating within a metal restricted environment impacts bacterial physiology.

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