» Articles » PMID: 22148076

A Rare Cause of Hypoglycaemia

Overview
Journal BMJ Case Rep
Specialty General Medicine
Date 2011 Dec 8
PMID 22148076
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

We describe the case of a 77-year-old man who was admitted with recurrent episodes of altered behaviour. These episodes were related to insulin-like growth factor II (IGF-II) mediated hypoglycaemia. Imaging revealed a large retroperitoneal mass and he underwent debulking surgery uneventfully. Histopathology revealed a solitary fibroma with intense immunostaining positive for CD34 and vimentin, suggesting a mesenchymal origin of the tumour. Later he received chemo/radiotherapy and is on prednisolone with abatement of hypoglycaemic episodes.

Citing Articles

Non-Islet Cell Tumor Hypoglycemia: A Rare Cause of Hypoglycemia in Pulmonary Sarcomatoid Cancer.

Legare T, Hamilton O, Dhannoon S, Ali S Cureus. 2018; 9(12):e1972.

PMID: 29492361 PMC: 5820013. DOI: 10.7759/cureus.1972.


Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature.

Dutta P, Aggarwal A, Gogate Y, Nahar U, Shah V, Singla M Endocrinol Diabetes Metab Case Rep. 2014; 2013:130046.

PMID: 24616774 PMC: 3922193. DOI: 10.1530/EDM-13-0046.

References
1.
BAXTER R, Holman S, Corbould A, Stranks S, Ho P, Braund W . Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab. 1995; 80(9):2700-8. DOI: 10.1210/jcem.80.9.7545698. View

2.
de Groot J, Rikhof B, van Doorn J, Bilo H, Alleman M, Honkoop A . Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases. Endocr Relat Cancer. 2007; 14(4):979-93. DOI: 10.1677/ERC-07-0161. View

3.
Trivedi N, Mithal A, Sharma A, Mishra S, Pandey R, Trivedi B . Non-islet cell tumour induced hypoglycaemia with acromegaloid facial and acral swelling. Clin Endocrinol (Oxf). 1995; 42(4):433-5. DOI: 10.1111/j.1365-2265.1995.tb02654.x. View

4.
Lloyd R, Erickson L, Nascimento A, Kloppel G . Neoplasms Causing Nonhyperinsulinemic Hypoglycemia. Endocr Pathol. 2002; 10(4):291-297. DOI: 10.1007/BF02739771. View

5.
Seckl M, Mulholland P, Bishop A, Teale J, Hales C, Glaser M . Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med. 1999; 341(10):733-6. DOI: 10.1056/NEJM199909023411004. View