A Facile Synthesis and Anticancer Activity Evaluation of Spiro[thiazolidinone-isatin] Conjugates

Overview

Journal Sci Pharm

Publisher MDPI

Specialty Pharmacology

Date 2011 Dec 7

PMID 22145104

Citations 12

Authors

Danylo Kaminskyy

Dmytro Khyluk

Olexandr Vasylenko

Lucjusz Zaprutko

Roman Lesyk

Affiliations

Soon will be listed here.

Abstract

The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the compounds was determined by (1)H and (13)C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.

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