Chlamydia Trachomatis Infection Control Programs: Lessons Learned and Implications for Vaccine Development

Overview

Journal Infect Dis Obstet Gynecol

Publisher Wiley

Specialties Gynecology & Obstetrics
Infectious Diseases

Date 2011 Dec 7

PMID 22144851

Citations 5

Authors

Jean M Chavez

Rodolfo D Vicetti Miguel

Thomas L Cherpes

Affiliations

Soon will be listed here.

Abstract

Chlamydia trachomatis control efforts that enhance detection and treatment of infected women may paradoxically increase susceptibility of the population to infection. Conversely, these surveillance programs lower incidences of adverse sequelae elicited by genital tract infection (e.g., pelvic inflammatory disease and ectopic pregnancy), suggesting enhanced identification and eradication of C. trachomatis simultaneously reduces pathogen-induced upper genital tract damage and abrogates formation of protective immune responses. In this paper, we detail findings from C. trachomatis infection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design.

Citing Articles

Molecular Evidence of Chlamydia trachomatis Infection and Its Relation to Miscarriage.

Bagheri S, Roghanian R, Golbang N, Golbang P, Nasr Esfahani M Int J Fertil Steril. 2018; 12(2):152-156.

PMID: 29707933 PMC: 5936614. DOI: 10.22074/ijfs.2018.5184.

Dendritic cell function and pathogen-specific T cell immunity are inhibited in mice administered levonorgestrel prior to intranasal Chlamydia trachomatis infection.

Quispe Calla N, Miguel R, Mei A, Fan S, Gilmore J, Cherpes T Sci Rep. 2016; 6:37723.

PMID: 27892938 PMC: 5125275. DOI: 10.1038/srep37723.

Fluorescent labeling reliably identifies Chlamydia trachomatis in living human endometrial cells and rapidly and accurately quantifies chlamydial inclusion forming units.

Miguel R, Henschel K, Lopez F, Quispe Calla N, Cherpes T J Microbiol Methods. 2015; 119:79-82.

PMID: 26453947 PMC: 4993108. DOI: 10.1016/j.mimet.2015.10.003.

Hypothesis: Chlamydia trachomatis infection of the female genital tract is controlled by Type 2 immunity.

Miguel R, Cherpes T Med Hypotheses. 2012; 79(6):713-6.

PMID: 22986006 PMC: 3496836. DOI: 10.1016/j.mehy.2012.07.032.

Transient detection of Chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection.

Miguel R, Reighard S, Chavez J, Rabe L, Maryak S, Wiesenfeld H Am J Reprod Immunol. 2012; 68(6):499-506.

PMID: 22934581 PMC: 3493686. DOI: 10.1111/aji.12008.

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