An Updated Analysis of Hepatitis C Virus Genotypes and Subtypes Based on the Complete Coding Region

Overview

Journal Liver Int

Specialty Gastroenterology

Date 2011 Dec 7

PMID 22142261

Citations 52

Authors

Tatsunori Nakano

Gillian M G Lau

Grace M L Lau

Masaya Sugiyama

Masashi Mizokami

Affiliations

Soon will be listed here.

Abstract

Background: The hepatitis C virus (HCV) genomic database is expanding rapidly.

Aims: There is a need to provide an updated phylogenetic tree analysis based on the complete coding region of HCV.

Methods: All available HCV complete genome sequences in the HCV databases available through October 2010 were analyzed.

Results: The assignment of all known complete sequences up-to-date confirmed the previous six major genotypes and one new sequence, which have been provisionally assigned as subtype 7a. New recombinant forms of HCV, although uncommon, have been detected and were found to have different crossover points.

Conclusion: This updated analysis based on the complete region of HCV confirmed the validity of the previously assigned genotypes/subtypes and provided an up-to-date reference for future basic research and clinical studies.

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