Thyroid Incidentalomas on Fluorine-18-fluorodeoxyglucose Positron Emission Tomography-computed Tomography: Incidence, Malignancy Risk, and Comparison of Standardized Uptake Values

Overview

Journal Can Assoc Radiol J

Publisher Sage Publications

Specialty Radiology

Date 2011 Dec 6

PMID 22136969

Citations 7

Authors

Yung H Kao

Siew S Lim

Seng C Ong

Ajit K Padhy

Affiliations

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Abstract

Introduction: To determine the incidence of fluorine-18-fluorodeoxyglucose (FDG) avid thyroid incidentalomas detected on positron emission tomography (PET) with integrated computed tomography (CT), and correlate the FDG-PET-CT findings to cytology.

Methods: A total of 942 FDG-PET-CT reports were retrospectively reviewed. Patients with FDG-avid thyroid incidentalomas were further reviewed for correlative cytology.

Results: The incidence of FDG-avid thyroid incidentalomas is 2.2%. Thyroid malignancies were identified in 3 of 6 patients who underwent cytologic correlation, with a positive predictive value of 50% (95% confidence interval, 14%-86%). The mean maximum standardized uptake values of benign and malignant FDG-avid thyroid incidentalomas were 5.6 and 6.6, respectively.

Conclusion: A FDG-avid thyroid incidentaloma may predict underlying malignancy. Cytologic assessment should be considered for FDG-avid thyroid incidentalomas.

Citing Articles

Definitions of Incidental [F]FDG PET/CT Findings in the Literature: A Systematic Review and Definition Proposal.

Molstrom J, Lange N, Pareek M, Thomassen A, Nielsen A, Hoilund-Carlsen P Diagnostics (Basel). 2024; 14(23).

PMID: 39682672 PMC: 11639948. DOI: 10.3390/diagnostics14232764.

Focal Thyroid Incidentalomas on F-FDG PET/CT: A Systematic Review and Meta-Analysis on Prevalence, Risk of Malignancy and Inconclusive Fine Needle Aspiration.

de Leijer J, Metman M, van der Hoorn A, Brouwers A, Kruijff S, van Hemel B Front Endocrinol (Lausanne). 2021; 12:723394.

PMID: 34744999 PMC: 8564374. DOI: 10.3389/fendo.2021.723394.

Characteristics of malignant thyroid lesions on [F] fluorodeoxyglucose (FDG)-Positron emission tomography (PET)/Computed tomography (CT).

Nasr H, Farghaly H, Alqarni A, Al-Salem S, Sayed M Eur J Radiol Open. 2021; 8:100373.

PMID: 34458507 PMC: 8379667. DOI: 10.1016/j.ejro.2021.100373.

Prevalence of incidental thyroid malignancy on routine F-fluorodeoxyglucose PET-CT in a large teaching hospital.

Roddy S, Biggans T, Raofi A, Kanodia A, Sudarshan T, Ramkumar P Eur J Hybrid Imaging. 2021; 4(1):21.

PMID: 34191154 PMC: 8218029. DOI: 10.1186/s41824-020-00089-5.

Clinical significance of thyroid incidentalomas detected on fluorodeoxyglucose positron emission tomography scan (PETomas): An Indian experience.

Kumar A, Datta G, Singh H, Mukherjee P, Vangal S World J Nucl Med. 2019; 18(3):273-282.

PMID: 31516371 PMC: 6714148. DOI: 10.4103/wjnm.WJNM_46_18.