Increased Oxidative Stress in Patients with Familial Mediterranean Fever During Attack Period

Overview

Journal Afr Health Sci

Date 2011 Dec 3

PMID 22135646

Citations 5

Authors

L Ediz

H Ozkol

I Tekeoglu

Y Tuluce

E Gulcu

I Koyuncu

Affiliations

Soon will be listed here.

Abstract

Objectives: We aimed to investigate the status of oxidant and antioxidants during attack period (AP) and attack free periods (AFP) in Familial Mediterranean fever (FMF) patients.

Methods: Measured the levels of malondialdehyde (MDA), protein carbonyl (PC), glutathione (GSH) and antioxidant vitamins (A,C and E) as well as the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) in serum and whole blood of FMF patients in FMF-AP and FMF-AFP.

Results: Levels of MDA and PC were found significantly higher (p <0.05) both in serum and whole blood of FMF-AP group compared with other groups. The CAT and GSH-Px activities in FMF-AP group were found markedly lower (p <0.05) comparing to HC group. However, there were no statistically significant differences between the groups in terms of antioxidant vitamin levels.

Conclusions: Our study demonstrated increased oxidative stress in patients with FMF during AP. Investigations are needed to establish the effect of antioxidant supplementation on FMF attack frequency and severity. We also suggest that these increased MDA and PC levels and decreased antioxidants may be used as supportive markers to differentiate AP from AFP. These conclusions need to be validated in further multicenter studies with high number of FMF patients.

Citing Articles

Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study.

Romano M, Garcia-Bournissen F, Piskin D, Rodoplu U, Piskin L, Elzagallaai A Life (Basel). 2022; 12(6).

PMID: 35743929 PMC: 9228597. DOI: 10.3390/life12060896.

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients.

Gurbuz O, Bagci B, Huzmeli C, Bagci G, Candan F Arch Rheumatol. 2018; 31(2):112-120.

PMID: 29900931 PMC: 5827825. DOI: 10.5606/ArchRheumatol.2016.5628.

Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?.

Omma A, Sandikci S, Kucuksahin O, Alisik M, Erel O J Korean Med Sci. 2017; 32(10):1588-1594.

PMID: 28875601 PMC: 5592171. DOI: 10.3346/jkms.2017.32.10.1588.

Distribution of MEFV gene mutations and R202Q polymorphism in the Serbian population and their influence on oxidative stress and clinical manifestations of inflammation.

Milenkovic J, Vojinovic J, Debeljak M, Toplak N, Lazarevic D, Avcin T Pediatr Rheumatol Online J. 2016; 14(1):39.

PMID: 27364639 PMC: 4929733. DOI: 10.1186/s12969-016-0097-1.

Increased levels of macrophage migration inhibitory factor in patients with familial mediterranean Fever.

Savran Y, Sari I, Kozaci D, Gunay N, Onen F, Akar S Int J Med Sci. 2013; 10(7):836-9.

PMID: 23794947 PMC: 3689875. DOI: 10.7150/ijms.6116.

References

Chae J, Aksentijevich I, Kastner D . Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol. 2009; 146(5):467-78. PMC: 2759843. DOI: 10.1111/j.1365-2141.2009.07733.x. View

Lee A, Chung S . Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J. 1999; 13(1):23-30. DOI: 10.1096/fasebj.13.1.23. View

Hassan M, Hadi R, Al-Rawi Z, Padron V, Stohs S . The glutathione defense system in the pathogenesis of rheumatoid arthritis. J Appl Toxicol. 2001; 21(1):69-73. DOI: 10.1002/jat.736. View

Levine R, Garland D, Oliver C, Amici A, Climent I, Lenz A . Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990; 186:464-78. DOI: 10.1016/0076-6879(90)86141-h. View

Aydin E, Sogut S, Ozyurt H, Ozugurlu F, Akyol O . Comparison of serum nitric oxide, malondialdehyde levels, and antioxidant enzyme activities in Behçet's disease with and without ocular disease. Ophthalmic Res. 2004; 36(3):177-82. DOI: 10.1159/000077332. View

Kose K, Yazici C, Cambay N, Ascioglu O, Dogan P . Lipid peroxidation and erythrocyte antioxidant enzymes in patients with Behçet's disease. Tohoku J Exp Med. 2002; 197(1):9-16. DOI: 10.1620/tjem.197.9. View

Buldanlioglu S, Turkmen S, Ayabakan H, Yenice N, Vardar M, Dogan S . Nitric oxide, lipid peroxidation and antioxidant defence system in patients with active or inactive Behçet's disease. Br J Dermatol. 2005; 153(3):526-30. DOI: 10.1111/j.1365-2133.2005.06543.x. View

Calder P, Albers R, Antoine J, Blum S, Bourdet-Sicard R, Ferns G . Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009; 101 Suppl 1:S1-45. DOI: 10.1017/S0007114509377867. View

Saglam K, Serce A, Yilmaz M, Bulucu F, Aydin A, Akay C . Trace elements and antioxidant enzymes in Behçet's disease. Rheumatol Int. 2002; 22(3):93-6. DOI: 10.1007/s00296-002-0195-x. View

10.

Kohen R, Nyska A . Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol. 2003; 30(6):620-50. DOI: 10.1080/01926230290166724. View

11.

Kirkali G, Tunca M, Genc S, Jaruga P, Dizdaroglu M . Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever. Free Radic Biol Med. 2007; 44(3):386-93. DOI: 10.1016/j.freeradbiomed.2007.09.020. View

12.

Heliovaara M, Knekt P, Aho K, Aaran R, Alfthan G, Aromaa A . Serum antioxidants and risk of rheumatoid arthritis. Ann Rheum Dis. 1994; 53(1):51-3. PMC: 1005243. DOI: 10.1136/ard.53.1.51. View

13.

MARTINEK R . METHOD FOR THE DETERMINATION OF VITAMIN E (TOTAL TOCOPHEROLS) IN SERUM. Clin Chem. 1964; 10:1078-86. View

14.

Ben-Chetrit E, Touitou I . Familial mediterranean Fever in the world. Arthritis Rheum. 2009; 61(10):1447-53. DOI: 10.1002/art.24458. View

15.

Kiziltunc A, Cogalgil S, Cerrahoglu L . Carnitine and antioxidants levels in patients with rheumatoid arthritis. Scand J Rheumatol. 1998; 27(6):441-5. DOI: 10.1080/030097498442271. View

16.

Schulz H, Niederau C, Halangk W, Luthen R, Lippert H . Oxidative stress in acute pancreatitis. Hepatogastroenterology. 1999; 46(29):2736-50. View

17.

Karaguezyan K, Haroutjunian V, Mamiconyan R, Hakobian G, Nazaretian E, Hovsepyan L . Evidence of oxidative stress in erythrocyte phospholipid composition in the pathogenesis of familial Mediterranean fever (periodical disease). J Clin Pathol. 1996; 49(6):453-5. PMC: 500532. DOI: 10.1136/jcp.49.6.453. View

18.

Comstock G, Burke A, Hoffman S, Helzlsouer K, Bendich A, MASI A . Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 1997; 56(5):323-5. PMC: 1752374. DOI: 10.1136/ard.56.5.323. View

19.

Hegde K, Henein M, Varma S . Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. Diabetes Obes Metab. 2003; 5(2):113-9. DOI: 10.1046/j.1463-1326.2003.00251.x. View

20.

Taysi S, Polat F, Gul M, Sari R, Bakan E . Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int. 2002; 21(5):200-4. DOI: 10.1007/s00296-001-0163-x. View