Catalytic Enantioselective 1,2-diboration of 1,3-dienes: Versatile Reagents for Stereoselective Allylation

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2011 Dec 3

PMID 22135105

Citations 43

Authors

Laura T Kliman

Scott N Mlynarski

Grace E Ferris

James P Morken

Affiliations

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Abstract

More with boron: The development of catalytic enantioselective 1,2-diboration of 1,3-dienes enables a new strategy for enantioselective carbonyl allylation reactions (see scheme). These reactions occur with outstanding levels of stereoselection and can be applied to both monosubstituted and 1,1-disubstituted dienes. The carbonyl allylation reactions provide enantiomerically enriched functionalized homoallylic alcohol products.

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