Planar Cell Polarity Signaling in Craniofacial Development

Overview

Journal Organogenesis

Specialties Anatomy & Histology
Biology
Biotechnology

Date 2011 Dec 3

PMID 22134372

Citations 14

Authors

Jacek Topczewski

Rodney M Dale

Barbara E Sisson

Affiliations

Soon will be listed here.

Abstract

Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.

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