Amyopathic Dermatomyositis Developing Rapidly Progressive Interstitial Lung Disease with Elevation of Anti-CADM-140/MDA5 Autoantibodies

Overview

Journal Mod Rheumatol

Publisher Oxford University Press

Specialty Rheumatology

Date 2011 Nov 30

PMID 22124544

Citations 12

Authors

Shinji Sato

Masataka Kuwana

Takashi Fujita

Yasuo Suzuki

Affiliations

Soon will be listed here.

Abstract

Anti-clinically amyopathic dermatomyositis (CADM)-140/MDA5 autoantibodies are specifically detected in patients with dermatomyositis and are known to have a strong association with rapidly progressive interstitial lung disease (RP-ILD). Here we report an amyopathic dermatomyositis (ADM) patient who developed RP-ILD characterized by elevated anti-CADM-140/MDA5 titer. Respiratory symptoms gradually improved, and anti-CADM-140/MDA5 titer decreased in parallel to below the cutoff level. It may be useful to quantify CADM-140-specific autoantibodies for monitoring disease activity in patients with ADM and RP-ILD.

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