Review of Bone Substitutes

Overview

Journal Craniomaxillofac Trauma Reconstr

Publisher Sage Publications

Date 2011 Nov 24

PMID 22110809

Citations 29

Authors

Landon S Pryor

Earl Gage

Claude-Jean Langevin

Fernando Herrera

Andrew D Breithaupt

Chad R Gordon

Ahmed M Afifi

James E Zins

Hal Meltzer

Amanda Gosman

Steve R Cohen

Ralph Holmes

Affiliations

Soon will be listed here.

Abstract

Bone substitutes are being increasingly used in craniofacial surgery and craniomaxillofacial trauma. We will review the history of the biomaterials and describe the ideal characteristics of bone substitutes, with a specific emphasis on craniofacial reconstruction. Some of the most commonly used bone substitutes are discussed in more depth, such as calcium phosphate and hydroxyapatite ceramics and cements, bioactive glass, and polymer products. Areas of active research and future directions include tissue engineering, with an increasing emphasis on bioactivity of the implant.

Citing Articles

Incorporating strontium enriched amorphous calcium phosphate granules in collagen/collagen-magnesium-hydroxyapatite osteochondral scaffolds improves subchondral bone repair.

Xu J, Vecstaudza J, Wesdorp M, Labberte M, Kops N, Salerno M Mater Today Bio. 2024; 25:100959.

PMID: 38327976 PMC: 10847994. DOI: 10.1016/j.mtbio.2024.100959.

Three-Dimensional Scaffolds for Bone Tissue Engineering.

Chinnasami H, Dey M, Devireddy R Bioengineering (Basel). 2023; 10(7).

PMID: 37508786 PMC: 10376773. DOI: 10.3390/bioengineering10070759.

Calcium Phosphate Delivery Systems for Regeneration and Biomineralization of Mineralized Tissues of the Craniofacial Complex.

Cuylear D, Elghazali N, Kapila S, Desai T Mol Pharm. 2023; 20(2):810-828.

PMID: 36652561 PMC: 9906782. DOI: 10.1021/acs.molpharmaceut.2c00652.

Bone Morphogenetic Protein as Bone Additive around Dental Implant and its Impact on Osseointegration: a Systematic Review.

Raza F, Vijayaragavalu S, Vaidyanathan A J Dent (Shiraz). 2023; 23(2 Suppl):336-348.

PMID: 36588970 PMC: 9789332. DOI: 10.30476/DENTJODS.2021.90931.1536.

Laser Sintering Approaches for Bone Tissue Engineering.

DiNoro J, Paxton N, Skewes J, Yue Z, Lewis P, Thompson R Polymers (Basel). 2022; 14(12).

PMID: 35745911 PMC: 9229946. DOI: 10.3390/polym14122336.

References

Moreira-Gonzalez A, Jackson I, Miyawaki T, Barakat K, DiNick V . Clinical outcome in cranioplasty: critical review in long-term follow-up. J Craniofac Surg. 2003; 14(2):144-53. DOI: 10.1097/00001665-200303000-00003. View

Liu H, Chen C, Tsai C, Lin I, Hsiue G . Heterobifunctional poly(ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cell differentiation and osteogenesis. Tissue Eng. 2007; 13(5):1113-24. DOI: 10.1089/ten.2006.0209. View

LeGeros R . Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res. 2002; (395):81-98. DOI: 10.1097/00003086-200202000-00009. View

Chung Y, Ahn K, Jeon S, Lee S, Lee J, Tae G . Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. J Control Release. 2007; 121(1-2):91-9. DOI: 10.1016/j.jconrel.2007.05.029. View

Cho Y, Gosain A . Biomaterials in craniofacial reconstruction. Clin Plast Surg. 2004; 31(3):377-85, v. DOI: 10.1016/j.cps.2004.03.001. View

Manson P, Crawley W, HOOPES J . Frontal cranioplasty: risk factors and choice of cranial vault reconstructive material. Plast Reconstr Surg. 1986; 77(6):888-904. View

Hoshino M, Namikawa T, Kato M, Terai H, Taguchi S, Takaoka K . Repair of bone defects in revision hip arthroplasty by implantation of a new bone-inducing material comprised of recombinant human BMP-2, Beta-TCP powder, and a biodegradable polymer: an experimental study in dogs. J Orthop Res. 2007; 25(8):1042-51. DOI: 10.1002/jor.20424. View

Fu Y, Nie H, Ho M, Wang C, Wang C . Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol Bioeng. 2007; 99(4):996-1006. DOI: 10.1002/bit.21648. View

Gosain A . Bioactive glass for bone replacement in craniomaxillofacial reconstruction. Plast Reconstr Surg. 2004; 114(2):590-3. DOI: 10.1097/01.prs.0000128355.95900.dd. View

10.

Cordioli G, Mazzocco C, Schepers E, Brugnolo E, Majzoub Z . Maxillary sinus floor augmentation using bioactive glass granules and autogenous bone with simultaneous implant placement. Clinical and histological findings. Clin Oral Implants Res. 2001; 12(3):270-8. DOI: 10.1034/j.1600-0501.2001.012003270.x. View

11.

Jensen T, Overgaard S, Lind M, Rahbek O, Bunger C, Soballe K . Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute: an experimental study in dogs. J Bone Joint Surg Br. 2007; 89(1):121-6. DOI: 10.1302/0301-620X.89B1.17077. View

12.

Elsalanty M, Por Y, Genecov D, Salyer K, Wang Q, Barcelo C . Recombinant human BMP-2 enhances the effects of materials used for reconstruction of large cranial defects. J Oral Maxillofac Surg. 2008; 66(2):277-85. DOI: 10.1016/j.joms.2007.06.626. View

13.

Eppley B, Kilgo M, Coleman 3rd J . Cranial reconstruction with computer-generated hard-tissue replacement patient-matched implants: indications, surgical technique, and long-term follow-up. Plast Reconstr Surg. 2002; 109(3):864-71. DOI: 10.1097/00006534-200203000-00005. View

14.

Okafuji N, Shimizu T, Watanabe T, Kimura A, Kurihara S, Furusawa K . Tissue reaction to poly (lactic-co-glycolic acid) copolymer membrane in rhBMP used rabbit experimental mandibular reconstruction. Eur J Med Res. 2006; 11(9):394-6. View

15.

Duskova M, Smahel Z, Vohradnik M, Tvrdek M, Mazanek J, Kozak J . Bioactive glass-ceramics in facial skeleton contouring. Aesthetic Plast Surg. 2002; 26(4):274-83. DOI: 10.1007/s00266-002-1032-z. View

16.

Eppley B . Craniofacial reconstruction with computer-generated HTR patient-matched implants: use in primary bony tumor excision. J Craniofac Surg. 2002; 13(5):650-7. DOI: 10.1097/00001665-200209000-00011. View

17.

Gibson I, Bonfield W . Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite. J Biomed Mater Res. 2002; 59(4):697-708. DOI: 10.1002/jbm.10044. View

18.

Eppley B, Sadove A, German R . Evaluation of HTR polymer as a craniomaxillofacial graft material. Plast Reconstr Surg. 1990; 86(6):1085-92. DOI: 10.1097/00006534-199012000-00006. View

19.

Eppley B . Biomechanical testing of alloplastic PMMA cranioplasty materials. J Craniofac Surg. 2005; 16(1):140-3. DOI: 10.1097/00001665-200501000-00028. View

20.

Burstein F, Williams J, Hudgins R, Boydston W, Reisner A, Stevenson K . Hydroxyapatite cement in craniofacial reconstruction: experience in 150 patients. Plast Reconstr Surg. 2006; 118(2):484-9. DOI: 10.1097/01.prs.0000234811.48147.64. View