Omega-3 Polyunsaturated Fatty Acids and Heart Rate Variability

Overview

Journal Front Physiol

Date 2011 Nov 24

PMID 22110443

Citations 28

Authors

Jeppe Hagstrup Christensen

Affiliations

Soon will be listed here.

Abstract

Omega-3 polyunsaturated fatty acids (PUFA) may modulate autonomic control of the heart because omega-3 PUFA is abundant in the brain and other nervous tissue as well as in cardiac tissue. This might partly explain why omega-3 PUFA offer some protection against sudden cardiac death (SCD). The autonomic nervous system is involved in the pathogenesis of SCD. Heart rate variability (HRV) can be used as a non-invasive marker of cardiac autonomic control and a low HRV is a predictor for SCD and arrhythmic events. Studies on HRV and omega-3 PUFA have been performed in several populations such as patients with ischemic heart disease, patients with diabetes mellitus, patients with chronic renal failure, and in healthy subjects as well as in children. The studies have demonstrated a positive association between cellular content of omega-3 PUFA and HRV and supplementation with omega-3 PUFA seems to increase HRV which could be a possible explanation for decreased risk of arrhythmic events and SCD sometimes observed after omega-3 PUFA supplementation. However, the results are not consistent and further research is needed.

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References

Park S, Tucker K, ONeill M, Sparrow D, Vokonas P, Hu H . Fruit, vegetable, and fish consumption and heart rate variability: the Veterans Administration Normative Aging Study. Am J Clin Nutr. 2009; 89(3):778-86. PMC: 2714396. DOI: 10.3945/ajcn.2008.26849. View

Mak K, Topol E . Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus. J Am Coll Cardiol. 2000; 35(3):563-8. DOI: 10.1016/s0735-1097(99)00628-2. View

BIGGER Jr J, Fleiss J, Steinman R, Rolnitzky L, Kleiger R, Rottman J . Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation. 1992; 85(1):164-71. DOI: 10.1161/01.cir.85.1.164. View

Dyerberg J, Eskesen D, Andersen P, Astrup A, Buemann B, Christensen J . Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur J Clin Nutr. 2004; 58(7):1062-70. DOI: 10.1038/sj.ejcn.1601934. View

Kleiger R, Stein P, Bosner M, Rottman J . Time domain measurements of heart rate variability. Cardiol Clin. 1992; 10(3):487-98. View

Herzog C, Mangrum J, Passman R . Sudden cardiac death and dialysis patients. Semin Dial. 2008; 21(4):300-7. DOI: 10.1111/j.1525-139X.2008.00455.x. View

DeGiorgio C, Miller P, Meymandi S, Gornbein J . n-3 fatty acids (fish oil) for epilepsy, cardiac risk factors, and risk of SUDEP: clues from a pilot, double-blind, exploratory study. Epilepsy Behav. 2008; 13(4):681-4. DOI: 10.1016/j.yebeh.2008.08.001. View

Denver J, Reed S, Porges S . Methodological issues in the quantification of respiratory sinus arrhythmia. Biol Psychol. 2006; 74(2):286-94. PMC: 1828207. DOI: 10.1016/j.biopsycho.2005.09.005. View

Stein P, Kleiger R . Insights from the study of heart rate variability. Annu Rev Med. 1999; 50:249-61. DOI: 10.1146/annurev.med.50.1.249. View

10.

Tsuji H, Larson M, Venditti Jr F, Manders E, Evans J, Feldman C . Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation. 1996; 94(11):2850-5. DOI: 10.1161/01.cir.94.11.2850. View

11.

Zipes D, Wellens H . Sudden cardiac death. Circulation. 1998; 98(21):2334-51. DOI: 10.1161/01.cir.98.21.2334. View

12.

Furlan R, Guzzetti S, Crivellaro W, Dassi S, Tinelli M, Baselli G . Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation. 1990; 81(2):537-47. DOI: 10.1161/01.cir.81.2.537. View

13.

Karemaker J . Autonomic integration: the physiological basis of cardiovascular variability. J Physiol. 1999; 517 ( Pt 2):316. PMC: 2269362. DOI: 10.1111/j.1469-7793.1999.0316t.x. View

14.

Chandra P, Sands R, Gillespie B, Levin N, Kotanko P, Kiser M . Predictors of heart rate variability and its prognostic significance in chronic kidney disease. Nephrol Dial Transplant. 2011; 27(2):700-9. PMC: 3616757. DOI: 10.1093/ndt/gfr340. View

15.

Akselrod S, Gordon D, Ubel F, Shannon D, Berger A, Cohen R . Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 1981; 213(4504):220-2. DOI: 10.1126/science.6166045. View

16.

Srinivasan K, Sucharita S, Vaz M . Effect of standing on short term heart rate variability across age. Clin Physiol Funct Imaging. 2002; 22(6):404-8. DOI: 10.1046/j.1475-097x.2002.00450.x. View

17.

Christensen J, Gustenhoff P, Korup E, Aaroe J, Toft E, Moller J . Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. BMJ. 1996; 312(7032):677-8. PMC: 2350515. DOI: 10.1136/bmj.312.7032.677. View

18.

Geelen A, Zock P, Swenne C, Brouwer I, Schouten E, Katan M . Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects. Am Heart J. 2003; 146(2):E4. DOI: 10.1016/S0002-8703(03)00441-1. View

19.

Taylor J, MYERS C, Halliwill J, Seidel H, Eckberg D . Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans. Am J Physiol Heart Circ Physiol. 2001; 280(6):H2804-14. DOI: 10.1152/ajpheart.2001.280.6.H2804. View

20.

Mozaffarian D, Geelen A, Brouwer I, Geleijnse J, Zock P, Katan M . Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation. 2005; 112(13):1945-52. DOI: 10.1161/CIRCULATIONAHA.105.556886. View