» Articles » PMID: 22110198

Silibinin Suppresses EGFR Ligand-induced CD44 Expression Through Inhibition of EGFR Activity in Breast Cancer Cells

Overview
Journal Anticancer Res
Specialty Oncology
Date 2011 Nov 24
PMID 22110198
Citations 14
Authors
Affiliations
Soon will be listed here.
Abstract

CD44, the transmembrane receptor for hyaluronan, is implicated in tumor cell invasion and metastasis. The expression of CD44 and its variants is associated with poor prognosis in breast cancer. Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle) on the epidermal growth factor (EGF) ligand-induced CD44 expression in human breast cancer cells. The levels of CD44 mRNA and protein expression were greatly increased by EGF and by TGF-α in SKBR3 and BT474 breast cancer cells. In contrast, EGFR ligand-induced CD44 expression was reduced by EGFR inhibitors, AG1478 and lapatinib, respectively. Interestingly, we observed that EGFR ligand-induced CD44 and matrix metalloproteinase-9 (MMP-9) expression was reduced by silibinin treatment in a dose-dependent manner. In addition, silibinin suppressed the EGF-induced phosphorylation of EGFR and extracellular signal-regulated kinase1/2 (ERK1/2), a downstream signaling molecule of EGFR. Therefore, we suggest that silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer.

Citing Articles

The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells.

Hossein-Tehrani M, Abbasalipourkabir R, Ziamajidi N Mol Biol Res Commun. 2024; 13(2):79-83.

PMID: 38504785 PMC: 10946549. DOI: 10.22099/MBRC.2024.48818.1903.


A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment.

Ray P, Islam M, Islam M, Han A, Geng P, Aziz M Front Pharmacol. 2024; 15:1349745.

PMID: 38487172 PMC: 10937417. DOI: 10.3389/fphar.2024.1349745.


Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.

Koltai T, Fliegel L J Evid Based Integr Med. 2022; 27:2515690X211068826.

PMID: 35018864 PMC: 8814827. DOI: 10.1177/2515690X211068826.


Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis.

Liu Y, Xie X, Hou X, Shen J, Shi J, Chen H J Nanobiotechnology. 2020; 18(1):83.

PMID: 32473632 PMC: 7260741. DOI: 10.1186/s12951-020-00638-x.


Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells.

Patel S, Waghela B, Shah K, Vaidya F, Mirza S, Patel S Sci Rep. 2018; 8(1):16985.

PMID: 30451890 PMC: 6242811. DOI: 10.1038/s41598-018-35069-0.