Neurohumoral Stimulation

Overview

Journal Heart Fail Clin

Specialty Cardiology & Vascular Diseases

Date 2011 Nov 24

PMID 22108729

Citations 60

Authors

Irving H Zucker

Kaushik P Patel

Harold D Schultz

Affiliations

Soon will be listed here.

Abstract

The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a compensatory mechanism switches to a deleterious contributing factor in the progression of the disease is unclear. This article addresses these issues through evaluating the contribution of various cardiovascular reflexes and cellular mechanisms to the sympathoexcitation in CHF. It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF.

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