Hematogenous Metastases in Patients with Stage I or II Endometrial Carcinoma

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2011 Nov 23

PMID 22105770

Citations 6

Authors

Pawel Blecharz

Krzysztof Urbanski

Anna Mucha-Malecka

Krzysztof Malecki

Marian Reinfuss

Jerzy Jakubowicz

Piotr Skotnicki

Affiliations

Soon will be listed here.

Abstract

Aims: The aim of this study was to present the characteristics, methods of treatment, and the survival of patients with hematogenous metastases from endometrial carcinoma, free from local and other distant recurrences.

Patients And Methods: In 1,610 endometrial carcinoma patients managed with surgery and postoperative radiotherapy, we defined hematogenous metastases as a tumor spread to the lung or other sites via hematogenous routes.

Results: A total of 110 patients with stage I and II endometrial carcinoma, presenting with 134 metastases sites (69 in the lungs, 32 in the liver, 23 in the bones, and 10 in the brain), were observed. Progestin and combination chemotherapy were the most commonly used therapies. Primary treatment consisted of surgery in patients with solitary metastases to the lung (30 patients), liver (2 patients), and brain (2 patients). Radiotherapy was performed in 32 patients with metastases to the brain and bones. Presenting with a 36-month survival rate were 11.6% (8/69) of patients with metastases to the lungs, 6.3% (2/32) of patients with metastases to the liver, 8.7% (2/23) of patients with metastases to the bones, and 20.0% (2/10) of patients with metastases to the brain.

Conclusions: Hormonal therapy and chemotherapy play a major role in the palliative management of patients with hematogenous metastases from endometrial carcinoma to the liver, lungs, and bones. Radical treatment in patients with metastases to the lung or liver consists of resection of the metastasis combined with chemo- and/or hormonotherapy for metastases to the bones treatment consists of radiotherapy + chemotherapy, for metastasis to the brain treatment consists of resection combined with radiotherapy.

Citing Articles

Brain Metastasis in Endometrial Cancer: A Systematic Review.

Sambataro D, Gebbia V, Bonasera A, Quattrocchi A, Caputo G, Vinci E Cancers (Basel). 2025; 17(3).

PMID: 39941769 PMC: 11816136. DOI: 10.3390/cancers17030402.

The oncologic outcomes of endometrial cancer metastasizing to the adrenal gland and kidney: from case to analysis.

Aytekin O, Kilic F, Ersak B, Unsal M, Akar S, Turkmen O J Turk Ger Gynecol Assoc. 2023; 24(3):172-176.

PMID: 37675503 PMC: 10493816. DOI: 10.4274/jtgga.galenos.2023.2022-11-3.

Therapeutic approaches in patients with bone metastasis due to endometrial carcinoma - A systematic review.

Heidinger M, Simonnet E, Koh L, Tirri B, Vetter M J Bone Oncol. 2023; 41:100485.

PMID: 37250286 PMC: 10213377. DOI: 10.1016/j.jbo.2023.100485.

Vaginal cuff brachytherapy in endometrial cancer - a technically easy treatment?.

Sabater S, Andres I, Lopez-Honrubia V, Berenguer R, Sevillano M, Jimenez-Jimenez E Cancer Manag Res. 2017; 9:351-362.

PMID: 28848362 PMC: 5557121. DOI: 10.2147/CMAR.S119125.

Liver recurrence in endometrial cancer: a multi-institutional analysis of factors predictive of postrecurrence survival.

Toptas T, Karalok A, Ureyen I, Tasci T, Erol O, Bozkurt S Clin Exp Metastasis. 2016; 33(7):707-15.

PMID: 27339214 DOI: 10.1007/s10585-016-9806-x.

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