Planar Multipolar Cells in the Cochlear Nucleus Project to Medial Olivocochlear Neurons in Mouse

Overview

Journal J Comp Neurol

Specialty Neurology

Date 2011 Nov 22

PMID 22101968

Citations 24

Authors

Keith N Darrow

Thane E Benson

M Christian Brown

Affiliations

Soon will be listed here.

Abstract

Medial olivocochlear (MOC) neurons originate in the superior olivary complex and project to the cochlea, where they act to reduce the effects of noise masking and protect the cochlea from damage. MOC neurons respond to sound via a reflex pathway; however, in this pathway the cochlear nucleus cell type that provides input to MOC neurons is not known. We investigated whether multipolar cells of the ventral cochlear nucleus have projections to MOC neurons by labeling them with injections into the dorsal cochlear nucleus. The projections of one type of labeled multipolar cell, planar neurons, were traced into the ventral nucleus of the trapezoid body, where they were observed terminating on MOC neurons (labeled in some cases by a second cochlear injection of FluoroGold). These terminations formed what appear to be excitatory synapses, i.e., containing small, round vesicles and prominent postsynaptic densities. These data suggest that cochlear nucleus planar multipolar neurons drive the MOC neuron's response to sound.

Citing Articles

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