Field Application of SPME As a Novel Tool for Occupational Exposure Assessment with Inhalational Anesthetics

Overview

Journal Environ Monit Assess

Publisher Springer

Specialty Environmental Health

Date 2011 Nov 18

PMID 22089627

Citations 4

Authors

Mohammad Javad Zare Sakhvidi

Abdulrahman Bahrami

Alireza Ghiasvand

Hossein Mahjub

Ludovic Tuduri

Affiliations

Soon will be listed here.

Abstract

Occupational exposure to inhalational anesthetics occurs routinely in operating rooms. It could induce serious health hazards and diseases. This exposure assessment is a crucial step in determining risks. In this study, a pen-shaped holder for solid-phase microextraction (SPME) sampler was successfully applied as a time-weighted average sampling tool for workshift exposure assessment of operation room staff to halothane. It proved to be very convenient for use in occupational environments such as operation rooms. Samples were analyzed by a gas chromatography-mass spectrometry. The validity of the SPME method was checked in real-world conditions with Occupational Safety and Health Administration (OSHA) 103 standard method for the determination of inhalational anesthetics. A good agreement between OSHA 103 and SPME methods was obtained and results demonstrated no statistically significant differences in anesthetic concentrations determined by the two analytical methods (p ≥ 0.05). It is concluded that SPME in retracted mode could successfully be applied in occupational exposure assessment purposes.

Citing Articles

Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes.

Kargar Shouroki F, Neghab M, Mozdarani H, Alipour H, Yousefinejad S, Fardid R Environ Sci Pollut Res Int. 2018; 26(4):3530-3541.

PMID: 30519912 DOI: 10.1007/s11356-018-3859-0.

Oxidative Stress Biomarkers in Exhaled Breath of Workers Exposed to Crystalline Silica Dust by SPME-GC-MS.

Jalali M, Sakhvidi M, Bahrami A, Berijani N, Mahjub H J Res Health Sci. 2016; 16(3):153-161.

PMID: 27840344 PMC: 7191029.

Application of mathematical models in combination with Monte Carlo simulation for prediction of isoflurane concentration in an operation room theater.

Sakhvidi M, Barkhordari A, Salehi M, Behdad S, Fallahzadeh H Ind Health. 2013; 51(5):545-51.

PMID: 23912206 PMC: 4202737. DOI: 10.2486/indhealth.2012-0130.

SPME-based air sampling method for inhalation exposure assessment studies: case study on perchlorethylene exposure in dry cleaning.

Sakhvidi M, Bahrami A, Ghiasvand A, Mahjub H, Tuduri L Environ Monit Assess. 2012; 185(6):4933-41.

PMID: 23054278 DOI: 10.1007/s10661-012-2914-4.

References

Tuduri L, Desauziers V, Fanlo J . Potential of solid-phase microextraction fibers for the analysis of volatile organic compounds in air. J Chromatogr Sci. 2002; 39(12):521-9. DOI: 10.1093/chromsci/39.12.521. View

Ouyang G, Pawliszyn J . SPME in environmental analysis. Anal Bioanal Chem. 2006; 386(4):1059-73. DOI: 10.1007/s00216-006-0460-z. View

Hoerauf K, Funk W, Harth M, Hobbhahn J . Occupational exposure to sevoflurane, halothane and nitrous oxide during paediatric anaesthesia. Waste gas exposure during paediatric anaesthesia. Anaesthesia. 1997; 52(3):215-9. DOI: 10.1111/j.1365-2044.1997.070-az0061.x. View

Korczynski R . Anesthetic gas exposure in veterinary clinics. Appl Occup Environ Hyg. 1999; 14(6):384-90. DOI: 10.1080/104732299302783. View

Irwin M, Trinh T, Yao C . Occupational exposure to anaesthetic gases: a role for TIVA. Expert Opin Drug Saf. 2009; 8(4):473-83. DOI: 10.1517/14740330903003778. View

Davenport H, Halsey M, Wardley-Smith B, Bateman P . Occupational exposure to anaesthetics in 20 hospitals. Anaesthesia. 1980; 35(4):354-9. DOI: 10.1111/j.1365-2044.1980.tb05116.x. View

Risticevic S, Niri V, Vuckovic D, Pawliszyn J . Recent developments in solid-phase microextraction. Anal Bioanal Chem. 2008; 393(3):781-95. DOI: 10.1007/s00216-008-2375-3. View

Poli D, Bergamaschi E, Manini P, Andreoli R, Mutti A . Solid-phase microextraction gas chromatographic-mass spectrometric method for the determination of inhalation anesthetics in urine. J Chromatogr B Biomed Sci Appl. 1999; 732(1):115-25. DOI: 10.1016/s0378-4347(99)00274-1. View

Bergemalm-Rynell K, Strandberg B, Andersson E, Sallsten G . Laboratory and field evaluation of a diffusive sampler for measuring halogenated anesthetic compounds. J Environ Monit. 2009; 10(10):1172-8. DOI: 10.1039/b809581g. View

10.

Khaled A, Pawliszyn J . Time-weighted average sampling of volatile and semi-volatile airborne organic compounds by the solid-phase microextraction device. J Chromatogr A. 2000; 892(1-2):455-67. DOI: 10.1016/s0021-9673(00)00295-8. View

11.

Jaloszynski P, Kujawski M, Wasowicz M, Szulc R, Szyfter K . Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay. Mutat Res. 1999; 439(2):199-206. DOI: 10.1016/s1383-5718(98)00195-8. View

12.

Tsai S, Kao K . Diffusive sampling of airborne furfural by solid-phase microextraction device with on-fiber derivatization. J Chromatogr A. 2006; 1129(1):29-33. DOI: 10.1016/j.chroma.2006.06.112. View

13.

Tsai S, Chang T . Time-weighted average sampling of airborne n-valeraldehyde by a solid-phase microextration device. J Chromatogr A. 2002; 954(1-2):191-8. DOI: 10.1016/s0021-9673(02)00152-8. View

14.

Koziel , Jia , Pawliszyn . Air sampling with porous solid-phase microextraction fibers. Anal Chem. 2000; 72(21):5178-86. DOI: 10.1021/ac000518l. View

15.

Wiesner G, Hoerauf K, Schroegendorfer K, Sobczynski P, Harth M, Ruediger H . High-level, but not low-level, occupational exposure to inhaled anesthetics is associated with genotoxicity in the micronucleus assay. Anesth Analg. 2001; 92(1):118-22. DOI: 10.1097/00000539-200101000-00023. View

16.

Otedo A . Halothane induced hepatitis: case report. East Afr Med J. 2005; 81(10):538-9. DOI: 10.4314/eamj.v81i10.9238. View

17.

ZENZ C . Reproductive risks in the workplace. Natl Saf News. 1984; 130(3):38-46. View

18.

Mazur J, Podolak G, Esposito G, Rinehart D, GLENN R . Evaluation of a passive dosimeter for collection of 2-bromo-2-chloro-1, 1, 1-trifluoroethane and 2-chloro-1, 1, 2-trifluoroethyl difluoromethyl ether in hospital operating rooms. Am Ind Hyg Assoc J. 1980; 41(5):317-21. DOI: 10.1080/15298668091424816. View

19.

Smith F . Management of exposure to waste anesthetic gases. AORN J. 2010; 91(4):482-94. DOI: 10.1016/j.aorn.2009.10.022. View

20.

Chen Y, Pawliszyn J . Solid-phase microextraction field sampler. Anal Chem. 2004; 76(22):6823-8. DOI: 10.1021/ac0490806. View