Vitamin D, Multiple Sclerosis and Inflammatory Bowel Disease

Overview

Journal Arch Biochem Biophys

Publisher Elsevier

Specialties Biochemistry
Biophysics

Date 2011 Nov 17

PMID 22085500

Citations 47

Authors

Margherita T Cantorna

Affiliations

Soon will be listed here.

Abstract

It has now been more than 20years since the vitamin D receptor was identified in cells of the immune system. The immune system has now been established as an important target of vitamin D. Vitamin D receptor knockout and vitamin D deficient mice have a surplus of effector T cells that have been implicated in the pathology of multiple sclerosis (MS) and inflammatory bowel disease (IBD). The active form of vitamin D directly and indirectly suppresses the function of these pathogenic T cells while inducing several regulatory T cells that suppress MS and IBD development. There is reason to believe that vitamin D could be an environmental factor that may play a role in the development of these immune mediated diseases in the clinic but at present there has not been a causal relationship established. Nonetheless, current evidence suggests that improving vitamin D status and/or using vitamin D receptor agonists may be useful in MS and IBD.

Citing Articles

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References

Pachner A . Experimental models of multiple sclerosis. Curr Opin Neurol. 2011; 24(3):291-9. DOI: 10.1097/WCO.0b013e328346c226. View

Iwakura Y, Ishigame H . The IL-23/IL-17 axis in inflammation. J Clin Invest. 2006; 116(5):1218-22. PMC: 1451213. DOI: 10.1172/JCI28508. View

Barrat F, Cua D, Boonstra A, Richards D, Crain C, Savelkoul H . In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med. 2002; 195(5):603-16. PMC: 2193760. DOI: 10.1084/jem.20011629. View

Tang J, Zhou R, Luger D, Zhu W, Silver P, Grajewski R . Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol. 2009; 182(8):4624-32. PMC: 2756755. DOI: 10.4049/jimmunol.0801543. View

Madsen K, Doyle J, Tavernini M, Jewell L, Rennie R, Fedorak R . Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology. 2000; 118(6):1094-105. DOI: 10.1016/s0016-5085(00)70362-3. View

Mayne C, Spanier J, Relland L, Williams C, Hayes C . 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol. 2011; 41(3):822-32. DOI: 10.1002/eji.201040632. View

Rook G . Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis. Immunology. 2009; 126(1):3-11. PMC: 2632706. DOI: 10.1111/j.1365-2567.2008.03007.x. View

Niller H, Wolf H, Ay E, Minarovits J . Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease. Adv Exp Med Biol. 2011; 711:82-102. DOI: 10.1007/978-1-4419-8216-2_7. View

Cristiano E, Patrucco L, Rojas J . A systematic review of the epidemiology of multiple sclerosis in South America. Eur J Neurol. 2008; 15(12):1273-8. DOI: 10.1111/j.1468-1331.2008.02330.x. View

10.

Fernandes De Abreu D, Ibrahim E, Boucraut J, Khrestchatisky M, Feron F . Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers. J Steroid Biochem Mol Biol. 2010; 121(1-2):250-3. DOI: 10.1016/j.jsbmb.2010.03.006. View

11.

Cantorna M, Mahon B . Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004; 229(11):1136-42. DOI: 10.1177/153537020422901108. View

12.

Correale J, Ysrraelit M, Gaitan M . Vitamin D-mediated immune regulation in multiple sclerosis. J Neurol Sci. 2011; 311(1-2):23-31. DOI: 10.1016/j.jns.2011.06.027. View

13.

Cantorna M, Munsick C, Bemiss C, Mahon B . 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr. 2000; 130(11):2648-52. DOI: 10.1093/jn/130.11.2648. View

14.

Chandran P, Satthaporn S, Robins A, Eremin O . Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II). Surgeon. 2004; 1(3):125-36. DOI: 10.1016/s1479-666x(03)80091-4. View

15.

Joshi S, Pantalena L, Liu X, Gaffen S, Liu H, Rohowsky-Kochan C . 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol. 2011; 31(17):3653-69. PMC: 3165548. DOI: 10.1128/MCB.05020-11. View

16.

Colin E, Asmawidjaja P, van Hamburg J, Mus A, van Driel M, Hazes J . 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum. 2009; 62(1):132-42. DOI: 10.1002/art.25043. View

17.

Yen D, Cheung J, Scheerens H, Poulet F, Mcclanahan T, McKenzie B . IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006; 116(5):1310-6. PMC: 1451201. DOI: 10.1172/JCI21404. View

18.

Jorgensen S, Agnholt J, Glerup H, Lyhne S, Villadsen G, Hvas C . Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010; 32(3):377-83. DOI: 10.1111/j.1365-2036.2010.04355.x. View

19.

Rai E, Wakeland E . Genetic predisposition to autoimmunity--what have we learned?. Semin Immunol. 2011; 23(2):67-83. DOI: 10.1016/j.smim.2011.01.015. View

20.

Meehan T, Deluca H . The vitamin D receptor is necessary for 1alpha,25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice. Arch Biochem Biophys. 2002; 408(2):200-4. DOI: 10.1016/s0003-9861(02)00580-5. View