Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum Perforatum L. in Rats

Overview

Journal ISRN Pharmacol

Date 2011 Nov 16

PMID 22084716

Citations 7

Authors

Gulam Mohammed Husain

Shyam Sunder Chatterjee

Paras Nath Singh

Vikas Kumar

Affiliations

Soon will be listed here.

Abstract

Hypericum perforatum is known to have diverse medicinal uses for centuries. The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder. Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats. Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days. Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats. Hypericum significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.

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References

Zavaroni I, Sander S, Scott S, Reaven G . Effect of fructose feeding on insulin secretion and insulin action in the rat. Metabolism. 1980; 29(10):970-3. DOI: 10.1016/0026-0495(80)90041-4. View

Husain G, Singh P, Kumar V . Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia. Drug Discov Ther. 2012; 3(5):215-20. View

Kumar V, Singh P, Jaiswal A, Bhattacharya S . Antidepressant activity of Indian Hypericum perforatum Linn in rodents. Indian J Exp Biol. 2000; 37(12):1171-6. View

Menegazzi M, Novelli M, Beffy P, DAleo V, Tedeschi E, Lupi R . Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. Int J Biochem Cell Biol. 2008; 40(8):1509-21. DOI: 10.1016/j.biocel.2007.11.019. View

FRIEDEWALD W, Levy R, Fredrickson D . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502. View

Chudasama H, Bhatt P . Evaluation of anti-obesity activity of duloxetine in comparison with sibutramine along with its anti-depressant activity: an experimental study in obese rats. Can J Physiol Pharmacol. 2009; 87(11):900-7. DOI: 10.1139/y09-080. View

Laggner H, Schreier S, Hermann M, Exner M, Muhl A, Gmeiner B . The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?. Free Radic Res. 2007; 41(2):234-41. DOI: 10.1080/10715760600978831. View

Kumar V, Khanna V, Seth P, Singh P, Bhattacharya S . Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn. Phytother Res. 2002; 16(3):210-6. DOI: 10.1002/ptr.1101. View

Jalal R, Bagheri S, Moghimi A, Rasuli M . Hypoglycemic effect of aqueous shallot and garlic extracts in rats with fructose-induced insulin resistance. J Clin Biochem Nutr. 2008; 41(3):218-23. PMC: 2243241. DOI: 10.3164/jcbn.2007031. View

10.

Levin B, Dunn-Meynell A, Balkan B, KEESEY R . Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol. 1997; 273(2 Pt 2):R725-30. DOI: 10.1152/ajpregu.1997.273.2.R725. View

11.

Kivimaki M, Hamer M, Batty G, Geddes J, Tabak A, Pentti J . Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study. Diabetes Care. 2010; 33(12):2611-6. PMC: 2992199. DOI: 10.2337/dc10-1187. View

12.

Chang S, Graham B, Yakubu F, Lin D, Peters J, Hill J . Metabolic differences between obesity-prone and obesity-resistant rats. Am J Physiol. 1990; 259(6 Pt 2):R1103-10. DOI: 10.1152/ajpregu.1990.259.6.R1103. View

13.

Serretti A, Mandelli L . Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010; 71(10):1259-72. DOI: 10.4088/JCP.09r05346blu. View

14.

Muller W, Rolli M, Schafer C, Hafner U . Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry. 1997; 30 Suppl 2:102-7. DOI: 10.1055/s-2007-979528. View

15.

Buettner R, Scholmerich J, Bollheimer L . High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring). 2007; 15(4):798-808. DOI: 10.1038/oby.2007.608. View

16.

Nakagawa T, Hu H, Zharikov S, Tuttle K, Short R, Glushakova O . A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2005; 290(3):F625-31. DOI: 10.1152/ajprenal.00140.2005. View

17.

Park O, Cesar D, Faix D, Wu K, Shackleton C, Hellerstein M . Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase. Biochem J. 1992; 282 ( Pt 3):753-7. PMC: 1130852. DOI: 10.1042/bj2820753. View

18.

Kumar V . Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006; 20(12):1023-35. DOI: 10.1002/ptr.1970. View

19.

Srinivasan K, Viswanad B, Asrat L, Kaul C, Ramarao P . Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005; 52(4):313-20. DOI: 10.1016/j.phrs.2005.05.004. View

20.

Yadav H, Jain S, Sinha P . Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition. 2006; 23(1):62-8. DOI: 10.1016/j.nut.2006.09.002. View