Can Pharmacogenomics Improve Malaria Drug Policy?

Overview

Journal Bull World Health Organ

Specialty Public Health

Date 2011 Nov 16

PMID 22084530

Citations 12

Authors

Mary W Roederer

Howard Mcleod

Jonathan J Juliano

Affiliations

Soon will be listed here.

Abstract

Coordinated global efforts to prevent and control malaria have been a tour-de-force for public health, but success appears to have reached a plateau in many parts of the world. While this is a multifaceted problem, policy strategies have largely ignored genetic variations in humans as a factor that influences both selection and dosing of antimalarial drugs. This includes attempts to decrease toxicity, increase effectiveness and reduce the development of drug resistance, thereby lowering health care costs. We review the potential hurdles to developing and implementing pharmacogenetic-guided policies at a national or regional scale for the treatment of uncomplicated falciparum malaria. We also consider current knowledge on some component drugs of artemisinin combination therapies and ways to increase our understanding of host genetics, with the goal of guiding policy decisions for drug selection.

Citing Articles

The Influence of Cytochrome P450 Polymorphisms on Pharmacokinetic Profiles and Treatment Outcomes Among Malaria Patients in Sub-Saharan Africa: A Systematic Review.

J Marwa K, Kapesa A, Kamugisha E, Swedberg G Pharmgenomics Pers Med. 2023; 16:449-461.

PMID: 37223718 PMC: 10202199. DOI: 10.2147/PGPM.S379945.

Xie Y, Liu H, Sun Y, Xing J Malar J. 2020; 19(1):71.

PMID: 32054478 PMC: 7020547. DOI: 10.1186/s12936-020-3153-8.

Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes.

Tshabalala S, Choudhury A, Beeton-Kempen N, Martinson N, Ramsay M, Mancama D Pharmacogenet Genomics. 2019; 29(7):167-178.

PMID: 31162291 PMC: 6675649. DOI: 10.1097/FPC.0000000000000380.

Effects of MAO-A and CYP450 on primaquine metabolism in healthy volunteers.

Ariffin N, Islahudin F, Kumolosasi E, Makmor-Bakry M Parasitol Res. 2019; 118(3):1011-1018.

PMID: 30706164 DOI: 10.1007/s00436-019-06210-3.

Factors Affecting Primaquine Combination Treatment in Malaria Patients in Selangor, Malaysia.

Ariffin N, Islahudin F, Makmor-Bakry M, Kumolosasi E, Hamid M J Pharm Bioallied Sci. 2018; 9(4):239-245.

PMID: 29456374 PMC: 5810073. DOI: 10.4103/jpbs.JPBS_48_17.

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