ADHDgene: a Genetic Database for Attention Deficit Hyperactivity Disorder

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2011 Nov 15

PMID 22080511

Citations 37

Authors

Liuyan Zhang

Suhua Chang

Zhao Li

Kunlin Zhang

Yang Du

Jurg Ott

Jing Wang

Affiliations

Soon will be listed here.

Abstract

With a worldwide prevalence of ~5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic susceptibility of ADHD have been increasing in recent years. There is a growing need to integrate the genetic data from various genetic studies to provide a comprehensive data set and uniform access for convenience of in-depth data mining. So far, there has been no such effort for ADHD. To address the genetic complexity of ADHD, we developed the ADHDgene database by integrating ADHD-related genetic factors by profound literature reading. Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database for ADHD, ADHDgene aims to provide researchers with a central genetic resource and analysis platform for ADHD and is freely available at http://adhd.psych.ac.cn/.

Citing Articles

Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues.

Zhao X, Song L, Yang A, Zhang Z, Zhang J, Yang Y Genome Med. 2023; 15(1):56.

PMID: 37488639 PMC: 10364416. DOI: 10.1186/s13073-023-01210-6.

Identifying rare genetic variants in 21 highly multiplex autism families: the role of diagnosis and autistic traits.

More R, Warrier V, Brunel H, Buckingham C, Smith P, Allison C Mol Psychiatry. 2023; 28(5):2148-2157.

PMID: 36702863 PMC: 10575770. DOI: 10.1038/s41380-022-01938-4.

Common genetic risk factors in ASD and ADHD co-occurring families.

Zhou A, Cao X, Mahaganapathy V, Azaro M, Gwin C, Wilson S Hum Genet. 2022; 142(2):217-230.

PMID: 36251081 PMC: 10177627. DOI: 10.1007/s00439-022-02496-z.

Study of changes in rs2283265 polymorphisms in dopamine receptor D2 and rs27072 in dopamine transporter gene (SLC6A3) in patients with attention-deficit hyperactivity disorder.

Safavi P, Soleimani Farsani H, Farrokhi E, Malekpour Tehrani A, Khoshdel N, Khoshdel A Iran J Child Neurol. 2022; 16(3):121-132.

PMID: 36204439 PMC: 9531196. DOI: 10.22037/ijcn.v15i4.25340.

Autism and ADHD in the Era of Big Data; An Overview of Digital Resources for Patient, Genetic and Clinical Trials Information.

Abomelha F, Aldhalaan H, Ghaziuddin M, Al-Tassan N, Al-Mubarak B Genes (Basel). 2022; 13(9).

PMID: 36140719 PMC: 9498424. DOI: 10.3390/genes13091551.

References

Faraone S, Perlis R, Doyle A, Smoller J, Goralnick J, Holmgren M . Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005; 57(11):1313-23. DOI: 10.1016/j.biopsych.2004.11.024. View

Fujita P, Rhead B, Zweig A, Hinrichs A, Karolchik D, Cline M . The UCSC Genome Browser database: update 2011. Nucleic Acids Res. 2010; 39(Database issue):D876-82. PMC: 3242726. DOI: 10.1093/nar/gkq963. View

Lasky-Su J, Neale B, Franke B, Anney R, Zhou K, Maller J . Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet. 2008; 147B(8):1345-54. DOI: 10.1002/ajmg.b.30867. View

Piletz J, Zhang X, Ranade R, Liu C . Database of genetic studies of bipolar disorder. Psychiatr Genet. 2010; 21(2):57-68. PMC: 3134528. DOI: 10.1097/YPG.0b013e328341a346. View

Williams N, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R . Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet. 2010; 376(9750):1401-8. PMC: 2965350. DOI: 10.1016/S0140-6736(10)61109-9. View

Zhang K, Chang S, Cui S, Guo L, Zhang L, Wang J . ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res. 2011; 39(Web Server issue):W437-43. PMC: 3125783. DOI: 10.1093/nar/gkr391. View

Coghill D, Banaschewski T . The genetics of attention-deficit/hyperactivity disorder. Expert Rev Neurother. 2009; 9(10):1547-65. DOI: 10.1586/ern.09.78. View

Biederman J, Faraone S . Attention-deficit hyperactivity disorder. Lancet. 2005; 366(9481):237-48. DOI: 10.1016/S0140-6736(05)66915-2. View

Jia P, Sun J, Guo A, Zhao Z . SZGR: a comprehensive schizophrenia gene resource. Mol Psychiatry. 2010; 15(5):453-62. PMC: 2861797. DOI: 10.1038/mp.2009.93. View

10.

Zhou K, Dempfle A, Arcos-Burgos M, Bakker S, Banaschewski T, Biederman J . Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008; 147B(8):1392-8. PMC: 2890047. DOI: 10.1002/ajmg.b.30878. View

11.

Neale B, Medland S, Ripke S, Asherson P, Franke B, Lesch K . Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010; 49(9):884-97. PMC: 2928252. DOI: 10.1016/j.jaac.2010.06.008. View

12.

Askland K, Read C, Moore J . Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet. 2008; 125(1):63-79. DOI: 10.1007/s00439-008-0600-y. View

13.

Poelmans G, Pauls D, Buitelaar J, Franke B . Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder. Am J Psychiatry. 2011; 168(4):365-77. DOI: 10.1176/appi.ajp.2010.10070948. View

14.

Mailman M, Feolo M, Jin Y, Kimura M, Tryka K, Bagoutdinov R . The NCBI dbGaP database of genotypes and phenotypes. Nat Genet. 2007; 39(10):1181-6. PMC: 2031016. DOI: 10.1038/ng1007-1181. View

15.

Mick E, Todorov A, Smalley S, Hu X, Loo S, Todd R . Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010; 49(9):898-905.e3. PMC: 3730251. DOI: 10.1016/j.jaac.2010.02.014. View

16.

Sherry S, Ward M, Kholodov M, Baker J, Phan L, Smigielski E . dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2000; 29(1):308-11. PMC: 29783. DOI: 10.1093/nar/29.1.308. View

17.

Polanczyk G, Silva de Lima M, Horta B, Biederman J, Rohde L . The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007; 164(6):942-8. DOI: 10.1176/ajp.2007.164.6.942. View

18.

Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N . The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry. 2006; 11(10):934-53. DOI: 10.1038/sj.mp.4001869. View

19.

Elia J, Gai X, Xie H, Perin J, Geiger E, Glessner J . Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol Psychiatry. 2009; 15(6):637-46. PMC: 2877197. DOI: 10.1038/mp.2009.57. View

20.

Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita K, Itoh M, Kawashima S . From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 2005; 34(Database issue):D354-7. PMC: 1347464. DOI: 10.1093/nar/gkj102. View