Mixed Exocrine and Endocrine Carcinoma in the Stomach: a Case Report

Overview

Journal J Gastric Cancer

Date 2011 Nov 15

PMID 22076213

Citations 14

Authors

Han Hong Lee

Chan Kwon Jung

Eun Sun Jung

Kyo Young Song

Hae Myung Jeon

Cho Hyun Park

Affiliations

Soon will be listed here.

Abstract

We report a rare case of the coexistence of a gastric small cell neuroendocrine carcinoma with a gastric adenocarcinoma. A 62-year-old man presented with epigastric soreness for 1 month. Esophagogastroduodenoscopy revealed a Borrmann type I tumor at the lesser curvature of the lower body of the stomach. The patient underwent a distal gastrectomy with D2 lymph node dissection and the resected specimen exhibited a 3.5×3.5 cm sized, fungating lesion. Two separated, not intermingling, lesions with non-adenocarcinoma components encircled by well differentiated adenocarcinoma components were identified microscopically. The non-adenocarcinoma component showed neuroendocrine features, such as a solid and trabecular pattern, and the tumor cells showed a high nuclear grade with minimal cytoplasm, indistinct nucleoli, and positive response for synaptophysin, CD56. The final pathological diagnosis was a gastric mixed exocrine-endocrine carcinoma (MEEC) composed of an adenocarcinoma and small cell neuroendocrine carcinoma of the collision type.

Citing Articles

Pancreatic Mixed Acinar-neuroendocrine Carcinoma in a Patient With a Germline Variant: A Case Report and Genomic Literature Review.

Saito Y, Suzuki S, Sanomachi T, Kato K, Otake H, Nishise Y In Vivo. 2025; 39(2):1173-1181.

PMID: 40010976 PMC: 11884457. DOI: 10.21873/invivo.13921.

Deficient Mismatch Repair Proteins in Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasm: A Rare Case Report.

Nguyen T, Nguyen Tran B, Nguyen T, Thi Ha T, Pham N, Nguyen T Case Rep Oncol. 2023; 16(1):1172-1182.

PMID: 37900850 PMC: 10601832. DOI: 10.1159/000533707.

Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.

Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z Cancer Med. 2021; 10(14):4855-4863.

PMID: 34109756 PMC: 8290235. DOI: 10.1002/cam4.4031.

Collision Tumor of the Stomach.

Kubo K, Takahashi R, Kimura N, Maiya N, Matsuda S, Tsuda M Case Rep Gastroenterol. 2021; 15(1):400-407.

PMID: 33976618 PMC: 8077467. DOI: 10.1159/000514395.

Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report.

Li X, Li D, Sun X, Lv G J Int Med Res. 2020; 48(8):300060520947918.

PMID: 32833541 PMC: 7448144. DOI: 10.1177/0300060520947918.

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