Gold Nanoparticles: Preparation, Properties, and Applications in Bionanotechnology

Overview

Journal Nanoscale

Specialty Biotechnology

Date 2011 Nov 15

PMID 22076024

Citations 277

Authors

Yi-Cheun Yeh

Brian Creran

Vincent M Rotello

Affiliations

Soon will be listed here.

Abstract

Gold nanoparticles (AuNPs) are important components for biomedical applications. AuNPs have been widely employed for diagnostics, and have seen increasing use in the area of therapeutics. In this mini-review, we present fabrication strategies for AuNPs and highlight a selection of recent applications of these materials in bionanotechnology.

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References

Khlebtsov N, Dykman L . Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev. 2010; 40(3):1647-71. DOI: 10.1039/c0cs00018c. View

Medley C, Smith J, Tang Z, Wu Y, Bamrungsap S, Tan W . Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal Chem. 2008; 80(4):1067-72. DOI: 10.1021/ac702037y. View

Dasary S, Singh A, Senapati D, Yu H, Ray P . Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc. 2009; 131(38):13806-12. DOI: 10.1021/ja905134d. View

Park S, Hamad-Schifferli K . Enhancement of in vitro translation by gold nanoparticle--DNA conjugates. ACS Nano. 2010; 4(5):2555-60. PMC: 2876231. DOI: 10.1021/nn100362m. View

Pons T, Medintz I, Sapsford K, Higashiya S, Grimes A, English D . On the quenching of semiconductor quantum dot photoluminescence by proximal gold nanoparticles. Nano Lett. 2007; 7(10):3157-64. DOI: 10.1021/nl071729+. View

Agasti S, Chompoosor A, You C, Ghosh P, Kim C, Rotello V . Photoregulated release of caged anticancer drugs from gold nanoparticles. J Am Chem Soc. 2009; 131(16):5728-9. PMC: 2673701. DOI: 10.1021/ja900591t. View

Huo Q, Colon J, Cordero A, Bogdanovic J, Baker C, Goodison S . A facile nanoparticle immunoassay for cancer biomarker discovery. J Nanobiotechnology. 2011; 9:20. PMC: 3127990. DOI: 10.1186/1477-3155-9-20. View

Templeton A, Wuelfing W, Murray R . Monolayer-protected cluster molecules. Acc Chem Res. 2000; 33(1):27-36. DOI: 10.1021/ar9602664. View

Guo S, Huang Y, Jiang Q, Sun Y, Deng L, Liang Z . Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano. 2010; 4(9):5505-11. PMC: 3044603. DOI: 10.1021/nn101638u. View

10.

Hong R, Han G, Fernandez J, Kim B, Forbes N, Rotello V . Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006; 128(4):1078-9. DOI: 10.1021/ja056726i. View

11.

Aydogan B, Li J, Rajh T, Chaudhary A, Chmura S, Pelizzari C . AuNP-DG: deoxyglucose-labeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging. Mol Imaging Biol. 2010; 12(5):463-7. DOI: 10.1007/s11307-010-0299-8. View

12.

Li X, Guo J, Asong J, Wolfert M, Boons G . Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions. J Am Chem Soc. 2011; 133(29):11147-53. PMC: 3153077. DOI: 10.1021/ja2012164. View

13.

Rosi N, Giljohann D, Thaxton C, Lytton-Jean A, Han M, Mirkin C . Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science. 2006; 312(5776):1027-30. DOI: 10.1126/science.1125559. View

14.

Phillips R, Miranda O, You C, Rotello V, Bunz U . Rapid and efficient identification of bacteria using gold-nanoparticle-poly(para-phenyleneethynylene) constructs. Angew Chem Int Ed Engl. 2008; 47(14):2590-4. DOI: 10.1002/anie.200703369. View

15.

Choi C, Alabi C, Webster P, Davis M . Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci U S A. 2010; 107(3):1235-40. PMC: 2824286. DOI: 10.1073/pnas.0914140107. View

16.

Miranda O, Li X, Garcia-Gonzalez L, Zhu Z, Yan B, Bunz U . Colorimetric bacteria sensing using a supramolecular enzyme-nanoparticle biosensor. J Am Chem Soc. 2011; 133(25):9650-3. PMC: 3120917. DOI: 10.1021/ja2021729. View

17.

Brown S, Nativo P, Smith J, Stirling D, Edwards P, Venugopal B . Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc. 2010; 132(13):4678-84. PMC: 3662397. DOI: 10.1021/ja908117a. View

18.

Zheng M, Huang X . Nanoparticles comprising a mixed monolayer for specific bindings with biomolecules. J Am Chem Soc. 2004; 126(38):12047-54. DOI: 10.1021/ja047029d. View

19.

Oh E, Hong M, Lee D, Nam S, Yoon H, Kim H . Inhibition assay of biomolecules based on fluorescence resonance energy transfer (FRET) between quantum dots and gold nanoparticles. J Am Chem Soc. 2005; 127(10):3270-1. DOI: 10.1021/ja0433323. View

20.

Kamat P, Barazzouk S, Hotchandani S . Electrochemical modulation of fluorophore emission on a nanostructured gold film. Angew Chem Int Ed Engl. 2002; 41(15):2764-7. DOI: 10.1002/1521-3773(20020802)41:15<2764::AID-ANIE2764>3.0.CO;2-E. View