The Absence of MyD88 Has No Effect on the Induction of Alternatively Activated Macrophage During Fasciola Hepatica Infection

Overview

Journal BMC Immunol

Publisher Biomed Central

Specialty Allergy & Immunology

Date 2011 Nov 15

PMID 22074389

Citations 3

Authors

Honglin Luo

Weiyi Huang

Dongying Wang

Haoju Wang

Kui Nie

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Alternatively activated macrophages (AAMφ) play important roles in allergies and responses toparasitic infections. However, whether signaling through toll-like receptors (TLRs) plays any role in AAMφ induction when young Fasciola hepatica penetrates the liver capsule and migrates through the liver tissue is still unclear.

Results: The data show that the lack of myeloid differentiation factor 88 (MyD88) has no effect on the AAMφ derived from the bone marrow (BMMφ) in vitro and does not impair the mRNA expression of arginase-1, resistin-like molecule (RELMα), and Ym1 in BMMφs. The Th2 cytokine production bias in splenocytes was not significantly altered in F. hepatica-infected mice in the absence of MyD88 in vitro and in the pleural cavity lavage in vivo. In addition, MyD88-deficiency has no effect on the arginase production of the F. hepatica elicited macrophages (Fe Mφs), production of RELMα and Ym1 proteins and mRNA expression of Ym1 and RELMα of macrophages in the peritoneal cavity 6 weeks post F. hepatica infection.

Conclusions: The absence of MyD88 has no effect on presence of AAMφ 6 weeks post F. hepatica infection.

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Retraction: The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection.

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References

Flynn R, Irwin J, Olivier M, Sekiya M, Dalton J, Mulcahy G . Alternative activation of ruminant macrophages by Fasciola hepatica. Vet Immunol Immunopathol. 2007; 120(1-2):31-40. DOI: 10.1016/j.vetimm.2007.07.003. View

Munder M, Eichmann K, Moran J, Centeno F, Soler G, Modolell M . Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol. 1999; 163(7):3771-7. View

Helmby H, Grencis R . Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection. Eur J Immunol. 2003; 33(11):2974-9. DOI: 10.1002/eji.200324264. View

deSchoolmeester M, Manku H, Else K . The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response. Infect Immun. 2006; 74(11):6280-6. PMC: 1695505. DOI: 10.1128/IAI.01609-05. View

Cliffe L, Grencis R . The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Adv Parasitol. 2004; 57:255-307. DOI: 10.1016/S0065-308X(04)57004-5. View

Koide N, Mu M, Hassan F, Islam S, Tumurkhuu G, Dagvadorj J . Lipopolysaccharide enhances interferon-gamma-induced nitric oxide (NO) production in murine vascular endothelial cells via augmentation of interferon regulatory factor-1 activation. J Endotoxin Res. 2007; 13(3):167-75. DOI: 10.1177/0968051907080894. View

Guzman-Morales J, Ariganello M, Hammami I, Thibault M, Jolicoeur M, Hoemann C . Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages. Biochem Biophys Res Commun. 2011; 405(4):538-44. DOI: 10.1016/j.bbrc.2011.01.063. View

Lee C, Hartl D, Lee G, Koller B, Matsuura H, Da Silva C . Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009; 206(5):1149-66. PMC: 2715037. DOI: 10.1084/jem.20081271. View

Holcomb I, Kabakoff R, Chan B, Baker T, Gurney A, Henzel W . FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000; 19(15):4046-55. PMC: 306596. DOI: 10.1093/emboj/19.15.4046. View

10.

Edwards J, Zhang X, Frauwirth K, Mosser D . Biochemical and functional characterization of three activated macrophage populations. J Leukoc Biol. 2006; 80(6):1298-307. PMC: 2642590. DOI: 10.1189/jlb.0406249. View

11.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H . Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003; 301(5633):640-3. DOI: 10.1126/science.1087262. View

12.

Carvalho L, Sun J, Kane C, Marshall F, Krawczyk C, Pearce E . Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function. Immunology. 2009; 126(1):28-34. PMC: 2632707. DOI: 10.1111/j.1365-2567.2008.03008.x. View

13.

Layland L, Wagner H, Prazeres Da Costa C . Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni-infected MyD88-/- mice. Eur J Immunol. 2005; 35(11):3248-57. DOI: 10.1002/eji.200526273. View

14.

Revaz-Breton M, Ronet C, Ives A, Hauyon-La Torre Y, Masina S, Tacchini-Cottier F . The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major. Eur J Immunol. 2010; 40(6):1697-707. DOI: 10.1002/eji.200939821. View

15.

Kawashima R, Kawamura Y, Kato R, Mizutani N, Toyama-Sorimachi N, Dohi T . IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Gastroenterology. 2006; 131(1):130-41. DOI: 10.1053/j.gastro.2006.04.022. View

16.

Donnelly S, ONeill S, Sekiya M, Mulcahy G, Dalton J . Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun. 2004; 73(1):166-73. PMC: 538930. DOI: 10.1128/IAI.73.1.166-173.2005. View

17.

Gupta R, Bajpai P, Tripathi L, Srivastava V, Jain S, Misra-Bhattacharya S . Macrophages in the development of protective immunity against experimental Brugia malayi infection. Parasitology. 2004; 129(Pt 3):311-23. DOI: 10.1017/s0031182004005682. View

18.

Raes G, Van den Bergh R, De Baetselier P, Hassanzadeh Ghassabeh G, Scotton C, Locati M . Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol. 2005; 174(11):6561. DOI: 10.4049/jimmunol.174.11.6561. View

19.

Anthony R, Urban Jr J, Alem F, Hamed H, Rozo C, Boucher J . Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med. 2006; 12(8):955-60. PMC: 1955764. DOI: 10.1038/nm1451. View

20.

Stein M, Keshav S, Harris N, Gordon S . Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med. 1992; 176(1):287-92. PMC: 2119288. DOI: 10.1084/jem.176.1.287. View