Adrenaline and Nocturnal Asthma

Overview

Journal BMJ

Specialty General Medicine

Date 1990 Sep 8

PMID 2207401

Citations 5

Authors

J F Morrison

C Teale

S B Pearson

P Marshall

N M Dwyer

S Jones

H G DEAN

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether the nocturnal fall in plasma adrenaline is a cause of nocturnal asthma.

Design: Double blind placebo controlled cross-over study. In the first experiment the nocturnal fall in plasma adrenaline at 4 am was corrected in 10 asthmatic subjects with an infusion of adrenaline after parasympathetic blockade with 30 micrograms/kg intravenous atropine. In the second experiment 11 asthmatic subjects showing similar variations in peak expiratory flow rate had the nocturnal fall in plasma adrenaline corrected by infusion before atropine was given.

Patients: Asthmatic subjects with a diurnal variation in home peak expiratory flow rate of greater than 20% for at least 75% of the time in the two weeks before the study.

Main Outcome Measures: Peak expiratory flow rate and plasma adrenaline.

Results: Correction of the nocturnal fall in plasma adrenaline at 4 am to resting 4 pm levels did not alter peak expiratory flow rate either before or after parasympathetic blockade with atropine.

Conclusion: A nighttime fall in plasma adrenaline is not a cause of nocturnal asthma.

Citing Articles

Humoral control of airway tone.

Thomson N, Dagg K, Ramsay S Thorax. 1996; 51(5):461-4.

PMID: 8711671 PMC: 473588. DOI: 10.1136/thx.51.5.461.

Nocturnal asthma.

Douglas N Thorax. 1993; 48(2):100-2.

PMID: 8493620 PMC: 464281. DOI: 10.1136/thx.48.2.100.

Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels.

Kennedy B, Bigby T, Ziegler M J Clin Invest. 1995; 95(6):2896-902.

PMID: 7769131 PMC: 295977. DOI: 10.1172/JCI117996.

Effects of H1-receptor blockade with terfenadine in nocturnal asthma.

Teale C, Morrison J, Pearson S Br J Clin Pharmacol. 1991; 32(3):371-3.

PMID: 1777375 PMC: 1368533. DOI: 10.1111/j.1365-2125.1991.tb03914.x.

Nocturnal asthma.

Macdonald J BMJ. 1992; 304(6833):998-9.

PMID: 1586812 PMC: 1881710. DOI: 10.1136/bmj.304.6833.998.

References

Morrison J, Pearson S . The effect of the circadian rhythm of vagal activity on bronchomotor tone in asthma. Br J Clin Pharmacol. 1989; 28(5):545-9. PMC: 1380014. DOI: 10.1111/j.1365-2125.1989.tb03540.x. View

Morice A, Sever P, Ind P . Adrenaline, bronchoconstriction, and asthma. Br Med J (Clin Res Ed). 1986; 293(6546):539-40. PMC: 1341313. DOI: 10.1136/bmj.293.6546.539. View

Catterall J, Rhind G, Stewart I, Whyte K, Shapiro C, Douglas N . Effect of sleep deprivation on overnight bronchoconstriction in nocturnal asthma. Thorax. 1986; 41(9):676-80. PMC: 460429. DOI: 10.1136/thx.41.9.676. View

Morrison J, Pearson S, DEAN H . Parasympathetic nervous system in nocturnal asthma. Br Med J (Clin Res Ed). 1988; 296(6634):1427-9. PMC: 2545890. DOI: 10.1136/bmj.296.6634.1427. View

Boschetto P, Roberts N, Rogers D, Barnes P . Effect of antiasthma drugs on microvascular leakage in guinea pig airways. Am Rev Respir Dis. 1989; 139(2):416-21. DOI: 10.1164/ajrccm/139.2.416. View

Ollerenshaw S, Jarvis D, Woolcock A, Sullivan C, Scheibner T . Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma. N Engl J Med. 1989; 320(19):1244-8. DOI: 10.1056/NEJM198905113201904. View

Berkin K, Inglis G, Ball S, Thomson N . Airway responses to low concentrations of adrenaline and noradrenaline in normal subjects. Q J Exp Physiol. 1985; 70(2):203-9. DOI: 10.1113/expphysiol.1985.sp002903. View

Da Prada M, ZURCHER . Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci. 1976; 19(8):1161-74. DOI: 10.1016/0024-3205(76)90251-4. View

Barnes P, Fitzgerald G, Brown M, Dollery C . Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. N Engl J Med. 1980; 303(5):263-7. DOI: 10.1056/NEJM198007313030506. View

10.

FitzGerald G, Barnes P, Hamilton C, Dollery C . Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man. Eur J Clin Invest. 1980; 10(5):401-6. DOI: 10.1111/j.1365-2362.1980.tb00052.x. View

11.

Hetzel M, Clark T . Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax. 1980; 35(10):732-8. PMC: 471372. DOI: 10.1136/thx.35.10.732. View

12.

Chen W, Chai H . Airway cooling and nocturnal asthma. Chest. 1982; 81(6):675-80. DOI: 10.1378/chest.81.6.675. View

13.

Berkin K, Inglis G, Ball S, Thomson N . Effect of low dose adrenaline and noradrenaline infusions on airway calibre in asthmatic patients. Clin Sci (Lond). 1986; 70(4):347-52. DOI: 10.1042/cs0700347. View