Structural Determination of the Functional Sites of E. Coli Elongation Factor Tu

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1990 Aug 27

PMID 2207145

Citations 11

Authors

B F Clark

M Kjeldgaard

T F la Cour

S Thirup

J Nyborg

Affiliations

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Abstract

Recently, we have made significant progress in solving the structure of a nicked form of elongation factor (EF)-Tu complexed with GDP. The structure has been refined to an R factor of 19.2% at 2.6 A resolution, so that most of the structure is clearly visible in the electron density map. Here we describe what is known about functional sites of EF-Tu in terms of the structure, which still lacks amino acids 40-60.

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